{"_buckets": {"deposit": "33facc06-e513-4651-8513-8dfaec280067"}, "_deposit": {"created_by": 1, "id": "736", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "736"}, "status": "published"}, "_oai": {"id": "oai:showa.repo.nii.ac.jp:00000736", "sets": ["96"]}, "author_link": ["4279", "4274", "4278", "4282", "4280", "4285", "4277", "4275", "4286", "4283", "4281", "4276", "4284"], "item_10002_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "103", "bibliographicPageStart": "95", "bibliographicVolumeNumber": "22", "bibliographic_titles": [{"bibliographic_title": "The Showa University journal of medical sciences"}]}]}, "item_10002_description_6": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "CXCL8/IL-8 is a chemoattractant for neutrophils and mast cells, and regulates inflammatory cell recruitment in allergy, infection, and other neutrophil-related diseases. Interferon (IFN) -γ-inducible protein 10 (CXCL10/IP-10) is a chemokine that attracts mononuclear cells, Th1 cells, and natural killer cells. We investigated the levels of CXCL8/IL-8 and CXCL10/IP-10 expression by airway epithelial cells after exposure to the inflammatory cytokines tumor necrosis factor (TNF) -α and IFN-γ, and to poly I:C, a synthetic analog of double-stranded RNA that is a ligand of Toll-like receptor 3 (TLR3). Poly I:C, TNF-α, IFN-γ, and combinations of poly I:C with TNF-α or IFN-γ were used to stimulate the airway epithelial cell line BEAS-2B. Following stimulation, we determined CXCL8/IL-8 and CXCL10/IP-10 mRNA levels by real-time PCR and protein levels by ELISA. Poly I:C treatment upregulated mRNA and protein expression for both CXCL8/IL-8 and CXCL10/IP-10. The addition of TNF-α, but not IFN-γ, to poly I:C further increased the expression of CXCL8/IL-8 mRNA and protein. The addition of either TNF-α or IFN-γ to the poly I:C treatment further increased CXCL10/IP-10 mRNA and protein expression. Cross-talk between TLR3 signaling and inflammatory cytokines regulates the expression of CXCL8/IL-8 and CXCL10/IP-10 in airway epithelial cells. From our results, TNF-α and IFN-γ produce different effects on TLR3 signaling.", "subitem_description_type": "Abstract"}]}, "item_10002_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Showa Medical Association and Showa University"}]}, "item_10002_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.15369/sujms.22.95", "subitem_relation_type_select": "DOI"}}]}, "item_10002_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10781651", "subitem_source_identifier_type": "NCID"}]}, "item_10002_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0915-6380", "subitem_source_identifier_type": "ISSN"}]}, "item_10002_text_26": {"attribute_name": "アイテムタイプ", "attribute_value_mlt": [{"subitem_text_value": "学内発行雑誌 / Departmental Bulletin Paper"}]}, "item_10002_text_27": {"attribute_name": "POS_INDEX", "attribute_value_mlt": [{"subitem_text_value": "学内発行雑誌/The Showa University journal of medical sciences/Vol.22(2010)/No.2"}]}, "item_10002_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "HOMMA, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "4274", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MATSUKURA, Satoshi"}], "nameIdentifiers": [{"nameIdentifier": "4275", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HIROSE, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "4276", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "OHNISHI, Tsukasa"}], "nameIdentifiers": [{"nameIdentifier": "4277", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KIMURA, Teruaki"}], "nameIdentifiers": [{"nameIdentifier": "4278", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KUROKAWA, Masatsugu"}], "nameIdentifiers": [{"nameIdentifier": "4279", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "IEKI, Koushi"}], "nameIdentifiers": [{"nameIdentifier": "4280", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ODAKA, Miho"}], "nameIdentifiers": [{"nameIdentifier": "4281", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SUZUKI, Shintaro"}], "nameIdentifiers": [{"nameIdentifier": "4282", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "WATANABE, Shin"}], "nameIdentifiers": [{"nameIdentifier": "4283", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SATO, Masayuki"}], "nameIdentifiers": [{"nameIdentifier": "4284", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KAWAGUCHI, Mio"}], "nameIdentifiers": [{"nameIdentifier": "4285", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ADACHI, Mitsuru"}], "nameIdentifiers": [{"nameIdentifier": "4286", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-07-26"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "S22_95.pdf", "filesize": [{"value": "394.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 394200.0, "url": {"label": "S22_95.pdf", "url": "https://showa.repo.nii.ac.jp/record/736/files/S22_95.pdf"}, "version_id": "adb7a5ec-83b6-4df3-9869-868189bbfe70"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Cross-talk between TLR3 and TNF-α or IFN-γ Signaling in Induction of CXCL8/IL-8 and CXCL10/IP-10 Expression in Airway Epithelial Cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Cross-talk between TLR3 and TNF-α or IFN-γ Signaling in Induction of CXCL8/IL-8 and CXCL10/IP-10 Expression in Airway Epithelial Cells", "subitem_title_language": "en"}]}, "item_type_id": "10002", "owner": "1", "path": ["96"], "permalink_uri": "https://showa.repo.nii.ac.jp/records/736", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-06-21"}, "publish_date": "2018-06-21", "publish_status": "0", "recid": "736", "relation": {}, "relation_version_is_last": true, "title": ["Cross-talk between TLR3 and TNF-α or IFN-γ Signaling in Induction of CXCL8/IL-8 and CXCL10/IP-10 Expression in Airway Epithelial Cells"], "weko_shared_id": 1}