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  1. 学内発行雑誌
  2. The Showa University journal of medical sciences
  3. Vol.22(2010)
  4. No.2

Cross-talk between TLR3 and TNF-α or IFN-γ Signaling in Induction of CXCL8/IL-8 and CXCL10/IP-10 Expression in Airway Epithelial Cells

https://showa.repo.nii.ac.jp/records/736
https://showa.repo.nii.ac.jp/records/736
b4776396-61d5-495e-abd3-f7549c5cc392
名前 / ファイル ライセンス アクション
S22_95.pdf S22_95.pdf (394.2 kB)
Item type 学内発行雑誌 / Departmental Bulletin Paper(1)
公開日 2018-06-21
タイトル
タイトル Cross-talk between TLR3 and TNF-α or IFN-γ Signaling in Induction of CXCL8/IL-8 and CXCL10/IP-10 Expression in Airway Epithelial Cells
言語
言語 eng
資源タイプ
資源タイプ departmental bulletin paper
著者 HOMMA, Tetsuya

× HOMMA, Tetsuya

HOMMA, Tetsuya

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MATSUKURA, Satoshi

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MATSUKURA, Satoshi

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HIROSE, Takashi

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HIROSE, Takashi

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OHNISHI, Tsukasa

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OHNISHI, Tsukasa

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KIMURA, Teruaki

× KIMURA, Teruaki

KIMURA, Teruaki

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KUROKAWA, Masatsugu

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KUROKAWA, Masatsugu

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IEKI, Koushi

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IEKI, Koushi

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ODAKA, Miho

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ODAKA, Miho

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SUZUKI, Shintaro

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SUZUKI, Shintaro

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WATANABE, Shin

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WATANABE, Shin

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SATO, Masayuki

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SATO, Masayuki

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KAWAGUCHI, Mio

× KAWAGUCHI, Mio

KAWAGUCHI, Mio

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ADACHI, Mitsuru

× ADACHI, Mitsuru

ADACHI, Mitsuru

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書誌情報 The Showa University journal of medical sciences

巻 22, 号 2, p. 95-103, 発行日 2010-06
抄録
内容記述タイプ Abstract
内容記述 CXCL8/IL-8 is a chemoattractant for neutrophils and mast cells, and regulates inflammatory cell recruitment in allergy, infection, and other neutrophil-related diseases. Interferon (IFN) -γ-inducible protein 10 (CXCL10/IP-10) is a chemokine that attracts mononuclear cells, Th1 cells, and natural killer cells. We investigated the levels of CXCL8/IL-8 and CXCL10/IP-10 expression by airway epithelial cells after exposure to the inflammatory cytokines tumor necrosis factor (TNF) -α and IFN-γ, and to poly I:C, a synthetic analog of double-stranded RNA that is a ligand of Toll-like receptor 3 (TLR3). Poly I:C, TNF-α, IFN-γ, and combinations of poly I:C with TNF-α or IFN-γ were used to stimulate the airway epithelial cell line BEAS-2B. Following stimulation, we determined CXCL8/IL-8 and CXCL10/IP-10 mRNA levels by real-time PCR and protein levels by ELISA. Poly I:C treatment upregulated mRNA and protein expression for both CXCL8/IL-8 and CXCL10/IP-10. The addition of TNF-α, but not IFN-γ, to poly I:C further increased the expression of CXCL8/IL-8 mRNA and protein. The addition of either TNF-α or IFN-γ to the poly I:C treatment further increased CXCL10/IP-10 mRNA and protein expression. Cross-talk between TLR3 signaling and inflammatory cytokines regulates the expression of CXCL8/IL-8 and CXCL10/IP-10 in airway epithelial cells. From our results, TNF-α and IFN-γ produce different effects on TLR3 signaling.
DOI
関連識別子 10.15369/sujms.22.95
出版者
出版者 Showa Medical Association and Showa University
ISSN
収録物識別子 0915-6380
著者版フラグ
出版タイプ VoR
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