| Item type |
学内発行雑誌 / Departmental Bulletin Paper(1) |
| 公開日 |
2019-08-09 |
| タイトル |
|
|
タイトル |
Inhibitory Effects of Chlorella Extract on Airway Hyperresponsiveness and Airway Remodeling in a Murine Model of Asthma |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
departmental bulletin paper |
| 著者 |
KUWAHARA, Naota
YAMAGUCHI, Munehiro
TANAKA, Akihiko
OHTA, Shin
UNO, Tomoki
UCHIDA, Yoshitaka
MANABE, Ryo
JINNO, Megumi
HIRAI, Kuniaki
MIYATA, Yoshito
MIZUMA, Hiroko
HOMMA, Tetsuya
YAMAMOTO, Mayumi
YAMAGUCHI, Fumihiro
KUSUMOTO, Sojiro
SUZUKI, Shintaro
OHNISHI, Tsukasa
SAGARA, Hironori
|
| 書誌情報 |
The Showa University journal of medical sciences
巻 31,
号 1,
p. 1-12,
発行日 2019-03
|
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Chlorella extract （CE） has been shown to induce production of T helper-1 cytokines, and regulate serum IgE levels in animal models of asthma. We aimed to evaluate whether CE could inhibit ovalbumin （OVA）-induced airway hyperresponsiveness （AHR） and airway remodeling in a murine model of asthma. Balb/c mice were allocated to four groups: a control group （no OVA exposure, not given CE）, a CE group （no OVA exposure, given CE）, an asthma group （sensitized/challenged with OVA, not given CE） and a CE＋asthma group （sensitized/challenged with OVA, given CE）. In the asthma and CE＋asthma groups, mice were sensitized with OVA on day 0 and day 12, and then challenged with OVA on three consecutive days. In the CE and CE＋asthma groups, the mice were given feed containing 2％ CE. We assessed AHR to methacholine, and analyzed bronchoalveolar lavage fluid （BALF）, serum, lung tissue and spleen cells. Administration of CE was associated with significantly lower AHR in OVA-sensitized and challenged mice. CE administration was also associated with marked reduction of total cells, eosinophils and T helper-2 cytokines （IL-4, IL-5 and IL-13） in BALF. In addition, administration of CE significantly decreased the numbers of periodic acid-Schiff （PAS）-positive cells in OVA-sensitized and challenged mice. Administration of CE also directly suppressed IL-4, IL-5 and IL-13 production in spleen cells of OVA-sensitized and challenged mice. These results indicate that CE can partly prevent AHR and airway remodeling in a murine model of asthma. |
| DOI |
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関連識別子 |
10.15369/sujms.31.1 |
| 出版者 |
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出版者 |
Showa University Society |
| ISSN |
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|
収録物識別子 |
0915-6380 |
| 著者版フラグ |
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出版タイプ |
VoR |
S31_1.pdf (611.6 kB)
