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  1. 学内発行雑誌
  2. The Showa University journal of medical sciences
  3. Vol.31(2019)
  4. No.1

Inhibitory Effects of Chlorella Extract on Airway Hyperresponsiveness and Airway Remodeling in a Murine Model of Asthma

https://showa.repo.nii.ac.jp/records/2985
https://showa.repo.nii.ac.jp/records/2985
5609fbbb-ee98-4e5b-9fb1-0ff0d4031b84
名前 / ファイル ライセンス アクション
S31_1.pdf S31_1.pdf (611.6 kB)
Item type 学内発行雑誌 / Departmental Bulletin Paper(1)
公開日 2019-08-09
タイトル
タイトル Inhibitory Effects of Chlorella Extract on Airway Hyperresponsiveness and Airway Remodeling in a Murine Model of Asthma
言語
言語 eng
資源タイプ
資源タイプ departmental bulletin paper
著者 KUWAHARA, Naota

× KUWAHARA, Naota

KUWAHARA, Naota

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YAMAGUCHI, Munehiro

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YAMAGUCHI, Munehiro

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TANAKA, Akihiko

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TANAKA, Akihiko

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OHTA, Shin

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OHTA, Shin

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UNO, Tomoki

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UNO, Tomoki

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UCHIDA, Yoshitaka

× UCHIDA, Yoshitaka

UCHIDA, Yoshitaka

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MANABE, Ryo

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MANABE, Ryo

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JINNO, Megumi

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JINNO, Megumi

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HIRAI, Kuniaki

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HIRAI, Kuniaki

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MIYATA, Yoshito

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MIYATA, Yoshito

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MIZUMA, Hiroko

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MIZUMA, Hiroko

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HOMMA, Tetsuya

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HOMMA, Tetsuya

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YAMAMOTO, Mayumi

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YAMAMOTO, Mayumi

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YAMAGUCHI, Fumihiro

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YAMAGUCHI, Fumihiro

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KUSUMOTO, Sojiro

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KUSUMOTO, Sojiro

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SUZUKI, Shintaro

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SUZUKI, Shintaro

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OHNISHI, Tsukasa

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OHNISHI, Tsukasa

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SAGARA, Hironori

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SAGARA, Hironori

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書誌情報 The Showa University journal of medical sciences

巻 31, 号 1, p. 1-12, 発行日 2019-03
抄録
内容記述タイプ Abstract
内容記述 Chlorella extract (CE) has been shown to induce production of T helper-1 cytokines, and regulate serum IgE levels in animal models of asthma. We aimed to evaluate whether CE could inhibit ovalbumin (OVA)-induced airway hyperresponsiveness (AHR) and airway remodeling in a murine model of asthma. Balb/c mice were allocated to four groups: a control group (no OVA exposure, not given CE), a CE group (no OVA exposure, given CE), an asthma group (sensitized/challenged with OVA, not given CE) and a CE+asthma group (sensitized/challenged with OVA, given CE). In the asthma and CE+asthma groups, mice were sensitized with OVA on day 0 and day 12, and then challenged with OVA on three consecutive days. In the CE and CE+asthma groups, the mice were given feed containing 2% CE. We assessed AHR to methacholine, and analyzed bronchoalveolar lavage fluid (BALF), serum, lung tissue and spleen cells. Administration of CE was associated with significantly lower AHR in OVA-sensitized and challenged mice. CE administration was also associated with marked reduction of total cells, eosinophils and T helper-2 cytokines (IL-4, IL-5 and IL-13) in BALF. In addition, administration of CE significantly decreased the numbers of periodic acid-Schiff (PAS)-positive cells in OVA-sensitized and challenged mice. Administration of CE also directly suppressed IL-4, IL-5 and IL-13 production in spleen cells of OVA-sensitized and challenged mice. These results indicate that CE can partly prevent AHR and airway remodeling in a murine model of asthma.
DOI
関連識別子 10.15369/sujms.31.1
出版者
出版者 Showa University Society
ISSN
収録物識別子 0915-6380
著者版フラグ
出版タイプ VoR
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