WEKO3
アイテム
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Visceral Fat Accumulation is Associated with Oxidative Stress and Increased Matrix Metalloproteinase-9 Expression in Atherogenic Factor-overlapped Model Rats
https://showa.repo.nii.ac.jp/records/746
https://showa.repo.nii.ac.jp/records/74676047388-3314-44b2-ac5b-dd89b34b62d1
名前 / ファイル | ライセンス | アクション |
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S22_27.pdf (1.1 MB)
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Item type | 学内発行雑誌 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-12-20 | |||||
タイトル | ||||||
タイトル | Visceral Fat Accumulation is Associated with Oxidative Stress and Increased Matrix Metalloproteinase-9 Expression in Atherogenic Factor-overlapped Model Rats | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | departmental bulletin paper | |||||
著者 |
TOMITA, Yuri
× TOMITA, Yuri× IWAI, Shinichi× KUMAI, Toshio× OHNUMA, Shigeko× KURAHASHI, Chika× TSUBOI, Asayo× OHBA, Keiichiro× ONO, Tomohiro× OKA, Yoshiomi× KOIKE, Jyunki× KOBAYASHI, Shinichi× OGUCHI, Katsuji |
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書誌情報 |
The Showa University journal of medical sciences 巻 22, 号 1, p. 27-40, 発行日 2010-03 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Visceral fat accumulation in lifestyle-related diseases increases the risk of atherosclerosis. Matrix metalloproteinases (MMPs) play an important role in the progression of atherosclerosis. We examined atherogenic factor-overlapped model rats to clarify the relationships among visceral fat, oxidative stress, and MMPs. We used four groups of male, 11-month-old, spontaneously hypertensive hyperlipidemic rats (SHHRs) or Sprague-Dawley (SD) rats. Animals were fed either a diet of high fat and 30% sucrose solution (HFDS) or a normal diet (ND) ad libitum for 6 months. The visceral fat weight increased by approximately three fold in SHHR-HFDS compared to SHHR-ND. The oxidative stress marker in plasma and MMP-9 mRNA expression in white blood cells increased in SHHR-HFDS compared to the other groups. A correlation was determined between oxidative stress and visceral fat or MMP-9 mRNA in all rats. Lipid deposition and immunostaining of CD68 and MMP-9 were observed mainly in the intima of aorta in SHHR-HFDS, while tissue inhibitor of metalloproteinase-1 mRNA expression decreased in both SHHR groups. The findings suggested that increased oxidative stress due to the visceral fat accumulation induced MMP-9 expression and macrophage accumulation in the intima of aorta in lifestyle-related disease model rats. | |||||
DOI | ||||||
関連識別子 | 10.15369/sujms.22.27 | |||||
出版者 | ||||||
出版者 | Showa Medical Association and Showa University | |||||
ISSN | ||||||
収録物識別子 | 0915-6380 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |