{"created":"2023-05-15T11:22:05.618319+00:00","id":746,"links":{},"metadata":{"_buckets":{"deposit":"0348499f-97a8-4a05-ad27-a9e064e9e085"},"_deposit":{"created_by":1,"id":"746","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"746"},"status":"published"},"_oai":{"id":"oai:showa.repo.nii.ac.jp:00000746","sets":["1:51:94:95"]},"author_link":["4342","4344","4351","4350","4343","4352","4346","4345","4347","4348","4349","4353"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"40","bibliographicPageStart":"27","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"The Showa University journal of medical sciences"}]}]},"item_10002_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Visceral fat accumulation in lifestyle-related diseases increases the risk of atherosclerosis. Matrix metalloproteinases (MMPs) play an important role in the progression of atherosclerosis. We examined atherogenic factor-overlapped model rats to clarify the relationships among visceral fat, oxidative stress, and MMPs. We used four groups of male, 11-month-old, spontaneously hypertensive hyperlipidemic rats (SHHRs) or Sprague-Dawley (SD) rats. Animals were fed either a diet of high fat and 30% sucrose solution (HFDS) or a normal diet (ND) ad libitum for 6 months. The visceral fat weight increased by approximately three fold in SHHR-HFDS compared to SHHR-ND. The oxidative stress marker in plasma and MMP-9 mRNA expression in white blood cells increased in SHHR-HFDS compared to the other groups. A correlation was determined between oxidative stress and visceral fat or MMP-9 mRNA in all rats. Lipid deposition and immunostaining of CD68 and MMP-9 were observed mainly in the intima of aorta in SHHR-HFDS, while tissue inhibitor of metalloproteinase-1 mRNA expression decreased in both SHHR groups. The findings suggested that increased oxidative stress due to the visceral fat accumulation induced MMP-9 expression and macrophage accumulation in the intima of aorta in lifestyle-related disease model rats.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Showa Medical Association and Showa University"}]},"item_10002_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.15369/sujms.22.27"}}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0915-6380"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TOMITA, Yuri"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IWAI, Shinichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KUMAI, Toshio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OHNUMA, Shigeko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KURAHASHI, Chika"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TSUBOI, Asayo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OHBA, Keiichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ONO, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OKA, Yoshiomi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOIKE, Jyunki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOBAYASHI, Shinichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OGUCHI, Katsuji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-26"}],"displaytype":"detail","filename":"S22_27.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S22_27.pdf","url":"https://showa.repo.nii.ac.jp/record/746/files/S22_27.pdf"},"version_id":"684e22ba-c208-4ad8-97ed-6a836f2379b0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"Visceral Fat Accumulation is Associated with Oxidative Stress and Increased Matrix Metalloproteinase-9 Expression in Atherogenic Factor-overlapped Model Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Visceral Fat Accumulation is Associated with Oxidative Stress and Increased Matrix Metalloproteinase-9 Expression in Atherogenic Factor-overlapped Model Rats"}]},"item_type_id":"10002","owner":"1","path":["95"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-12-20"},"publish_date":"2016-12-20","publish_status":"0","recid":"746","relation_version_is_last":true,"title":["Visceral Fat Accumulation is Associated with Oxidative Stress and Increased Matrix Metalloproteinase-9 Expression in Atherogenic Factor-overlapped Model Rats"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-05-15T12:36:37.185405+00:00"}