@article{oai:showa.repo.nii.ac.jp:00000746,
 author = {TOMITA, Yuri and IWAI, Shinichi and KUMAI, Toshio and OHNUMA, Shigeko and KURAHASHI, Chika and TSUBOI, Asayo and OHBA, Keiichiro and ONO, Tomohiro and OKA, Yoshiomi and KOIKE, Jyunki and KOBAYASHI, Shinichi and OGUCHI, Katsuji},
 issue = {1},
 journal = {The Showa University journal of medical sciences},
 month = {2010-03, 2019-07-26},
 note = {Visceral fat accumulation in lifestyle-related diseases increases the risk of atherosclerosis. Matrix metalloproteinases (MMPs) play an important role in the progression of atherosclerosis. We examined atherogenic factor-overlapped model rats to clarify the relationships among visceral fat, oxidative stress, and MMPs. We used four groups of male, 11-month-old, spontaneously hypertensive hyperlipidemic rats (SHHRs) or Sprague-Dawley (SD) rats. Animals were fed either a diet of high fat and 30% sucrose solution (HFDS) or a normal diet (ND) ad libitum for 6 months. The visceral fat weight increased by approximately three fold in SHHR-HFDS compared to SHHR-ND. The oxidative stress marker in plasma and MMP-9 mRNA expression in white blood cells increased in SHHR-HFDS compared to the other groups. A correlation was determined between oxidative stress and visceral fat or MMP-9 mRNA in all rats. Lipid deposition and immunostaining of CD68 and MMP-9 were observed mainly in the intima of aorta in SHHR-HFDS, while tissue inhibitor of metalloproteinase-1 mRNA expression decreased in both SHHR groups. The findings suggested that increased oxidative stress due to the visceral fat accumulation induced MMP-9 expression and macrophage accumulation in the intima of aorta in lifestyle-related disease model rats.},
 pages = {27--40},
 title = {Visceral Fat Accumulation is Associated with Oxidative Stress and Increased Matrix Metalloproteinase-9 Expression in Atherogenic Factor-overlapped Model Rats},
 volume = {22},
 year = {}
}