| Item type |
学内発行雑誌 / Departmental Bulletin Paper(1) |
| 公開日 |
2016-12-20 |
| タイトル |
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タイトル |
Mast Cell Infiltration is Associated with Myelofibrosis and Angiogenesis in Myelodysplastic Syndromes |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ |
departmental bulletin paper |
| 著者 |
HOMMA, Mayumi
TAKIMOTO, Masafumi
ARIIZUMI, Hirotsugu
SHIOZAWA, Eisuke
YAMOCHI-ONIZUKA, Toshiko
KUSHIMA, Miki
HATTORI, Norimichi
MAEDA, Takashi
NAKASHIMA, Hidetoshi
SAITO, Bungo
YANAGISAWA, Kouji
MATSUDA, Isao
NAKAMAKI, Tsuyoshi
TOMOYASU, Shigeru
OTA, Hidekazu
|
| 書誌情報 |
The Showa University journal of medical sciences
巻 22,
号 1,
p. 51-61,
発行日 2010-03
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Myelodysplastic syndromes are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by persistent peripheral cytopenia with morphological and functional abnormalities of hematopoietic cells. Mast cells infiltrate into or around tumor tissues and play a role in remodeling of the stromal microenvironment, contributing to tumor progression. Increased mast cell numbers are associated with fibrosis, angiogenesis and a poor prognosis in human carcinomas. The aim of this study was to determine whether mast cell infiltration contributes to myelofibrosis or angiogenesis in myelodysplastic syndromes. We evaluated the correlation between mast cell density and the extent of myelofibrosis and angiogenesis in myelodysplastic syndromes. Fifty bone marrow biopsies taken from patients with a diagnosis of myelodysplastic syndromes were examined. Grading of myelofibrosis was evaluated by silver impregnation staining. Mast cell density and microvessel density were evaluated by immunohistochemistry. Human mast cells have been divided into two phenotypes. We designated a tryptase-positive mast cell as MCT and a chymase-positive mast cell as MCTC. Microvessels were identified by CD34-positive endothelial cells. Microvessel density and the extent of myelofibrosis were significantly greater in patients with high MCT and MCTC density compared to those with low MC density. Based on this, we suggest that the presence of high mast cell numbers is associated with myelofibrosis and angiogenesis in myelodysplastic syndromes. |
| DOI |
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関連識別子 |
10.15369/sujms.22.51 |
| 出版者 |
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出版者 |
Showa Medical Association and Showa University |
| ISSN |
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収録物識別子 |
0915-6380 |
| 出版タイプ |
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出版タイプ |
VoR |
S22_51.pdf (341.7 kB)
