| Item type |
学内発行雑誌 / Departmental Bulletin Paper(1) |
| 公開日 |
2017-10-05 |
| タイトル |
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タイトル |
Higher Adiponectin Expression Suppresses Neointimal Hyperplasia by Attenuating the Inflammatory Response Following Acceleration of Endothelialization in Damaged Areas in Adiponectin Transgenic Mice |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ |
departmental bulletin paper |
| 著者 |
OMORI, Yasutoshi
SUZUKI, Hiroshi
SAITO, Kiyomi
SHOJI, Makoto
ISO, Yoshitaka
NEGORO, Takaharu
KOBA, Shinji
NAKANO, Yasuko
KOBAYASHI, Youichi
|
| 書誌情報 |
The Showa University journal of medical sciences
巻 29,
号 2,
p. 107-117,
発行日 2017-06
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Adiponectin prevents inflammation and atherosclerosis, but it is unclear whether overexpression of adiponectin protects the vasculature. The aim of the present study was to determine whether adiponectin overexpression promotes vascular repair after mechanical injury using adiponectin transgenic (Tg) mice. Studies were performed in 7–8-week-old C57/BL6 (wild-type; WT; n=50) and adiponectin Tg (n=46) mice. A damaged endothelium model was created by inserting a large wire into the femoral artery. Von Willebrand factor-positive cells were observed on the surface of the damaged area from 1 week after wire injury in Tg mice, and from 2 weeks in WT mice. At 1 week, both α-smooth muscle embryonic myosin heavy chain-positive cells and intercellular adhesion molecule-positive cells were observed in the neointima in WT but not Tg mice. The intima/media ratio was significantly smaller in Tg than WT mice. Adiponectin and tumor necrosis factor (TNF)-α mRNA expression was observed in non-injured Tg and WT mice, but serum and mesenteric adipose tissue adiponectin concentrations were significantly higher in Tg than WT mice. Higher adiponectin and lower TNF-α levels, brought about by adiponectin transgene expression, suppressed neointimal hyperplasia by attenuating the inflammatory response following the acceleration of endothelialization in damaged areas in adiponectin Tg mice. |
| DOI |
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関連タイプ |
isIdenticalTo |
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関連識別子 |
10.15369/sujms.29.107 |
| 出版者 |
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出版者 |
Showa University Society |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0915-6380 |
| 出版タイプ |
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出版タイプ |
VoR |
S29_107.pdf (872.8 kB)
