| Item type |
学内発行雑誌 / Departmental Bulletin Paper(1) |
| 公開日 |
2021-07-28 |
| タイトル |
|
|
タイトル |
Clinicopathological study on pIgR expression and tumor progression in advanced colorectal cancer |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
departmental bulletin paper |
| 著者 |
KIKUCHI, Kazuo
OHIKE, Nobuyuki
NOROSE, Tomoko
YOSHIDA, Hitoshi
OGAWA, Takashi
YAMOCHI, Toshiko
|
| 書誌情報 |
The Showa University journal of medical sciences
巻 33,
号 2,
p. 41-46,
発行日 2021-06
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
This study is aimed at investigating the relationship between the polymeric immunoglobulin receptor （pIgR） expression and clinicopathological factors in advanced colorectal cancer （CRC） patients. The study involved 47 advanced CRC patients who were surgically resected and underwent KRAS gene test. The pIgR expression was analyzed by immunohistochemistry, and the patients were classified into high and low （pIgR-H and pIgR-L, respectively） groups based on the staining intensity and range. A total of 13 cases was classified under the pIgR-H group, and the remaining 34 were classified under the pIgR-L group. Results suggest no significant differences in most clinicopathological factors between the pIgR-H and pIgR-L groups, although the pIgR-L group had a significantly higher frequency of venous invasion than the pIgR-H group, whereas the frequency of KRAS gene mutation was significantly higher in the pIgR-H group than that in the pIgR-L group. The findings in this study showed little significant correlation between the pIgR expression and clinicopathological factors in advanced CRC patients. Further research on the biological behavior of pIgR as a drug treatment option for KRAS-mutated advanced CRCs is also warranted. |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
関連識別子 |
10.15369/sujms.33.41 |
| 出版者 |
|
|
出版者 |
Showa University Society |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2185-0968 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
S33_41.pdf (287.8 kB)
