| Item type |
学内発行雑誌 / Departmental Bulletin Paper(1) |
| 公開日 |
2021-07-28 |
| タイトル |
|
|
タイトル |
A comparative study of asthma with airflow limitation and asthma-COPD overlap using the forced oscillation technique |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
departmental bulletin paper |
| 著者 |
SATO, Hiroki
TANAKA, Akihiko
HIRAI, Kuniaki
EBATO, Takaya
INOUE, Hideki
HOMMA, Tetsuya
OHTA, Shin
SUZUKI, Shintaro
SAGARA, Hironori
|
| 書誌情報 |
The Showa University journal of medical sciences
巻 33,
号 2,
p. 25-33,
発行日 2021-06
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The forced oscillation technique（FOT）, which requires breathing without forced action, is a useful tool that can measure respiratory impedance. We investigated the physiological differences between asthma with smoking-unrelated airflow limitation and asthma-chronic obstructive pulmonary disease（COPD）overlap（ACO）using the FOT. Among 275 patients with asthma who presented at the Showa University Hospital from April 2018 through March 2019, 211 were enrolled and assigned into the asthma（BA）, asthma with airflow limitation（AL）, or ACO groups. Respiratory impedance measured using the FOT were compared among the groups. There were no significant differences in spirometry data between the AL and the ACO group. The AL group had higher respiratory resistance at 5Hz（R5）, 20Hz（R20）, and reactance at 5Hz than the ACO group, but there was no significant difference in subtracting R20 from R5（R5-R20）. R5 and R20 were similar between the ACO and the BA groups, but R5-R20, resonant frequency（Fres）, and low-frequency reactance area were significantly higher in the ACO group than the BA group. Fres yielded the highest area under the curve（AUC）to identify airflow limitation, and R20 yielded the highest AUC to identify the ACO group among patients with airflow limitation. An analysis using the cut off value to identify airflow limitation and ACO detected 33 patients as having ACO, 17 of whom were diagnosed with ACO. R5 and R20 measured by FOT are higher in AL than in ACO despite no difference in spirometry data, and are not significantly different between BA and ACO. Therefore, FOT aids our understanding of the physiological characteristics and provides clues for the treatment in asthmatics with airflow limitation. |
| DOI |
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|
|
関連識別子 |
10.15369/sujms.33.25 |
| 出版者 |
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|
出版者 |
Showa University Society |
| ISSN |
|
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収録物識別子 |
2185-0968 |
| 著者版フラグ |
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|
出版タイプ |
VoR |
S33_25.pdf (337.6 kB)
