| Item type |
学内発行雑誌 / Departmental Bulletin Paper(1) |
| 公開日 |
2020-06-01 |
| タイトル |
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|
タイトル |
Assessment of Hepatocellular Carcinoma Ablation Margins Using Fused Pre-ablation Hepatobiliary Phase and Post-ablation Unenhanced T1-weighted Images |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ |
departmental bulletin paper |
| 著者 |
TAKEYAMA, Nobuyuki
MIZOBUCHI, Naruki
SAKAKI, Masashi
SHIMOZUMA, Yu
KAJIWARA, Atsushi
UCHIKOSHI, Manabu
MUNECHIKA, Jiro
UOZUMI, Syojiro
OHGIYA, Yoshimitsu
HASHIMOTO, Toshi
|
| 書誌情報 |
The Showa University journal of medical sciences
巻 31,
号 4,
p. 339-353,
発行日 2019-12
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
This study retrospectively investigated the value of fusing a pre-ablation hepatobiliary phase（HBP）series and post-ablation unenhanced T1-weighted images（T1WIs）to evaluate the treatment effectiveness of radiofrequency ablation for hepatocellular carcinoma（HCC）. Predictors of local tumor progression（LTP）were also identified. Our study comprised 47 patients with 88 HCCs（＞2 years follow up）who underwent pre-ablation gadoxetate disodium-enhanced magnetic resonance imaging and post-ablation T1-weighted imaging. For the new assessment, pre-ablation HBP series and post-ablation T1WIs were fused using a rigid registration and manual correlation, and the ablation margin appearance was classified as ablation margin（＋）, ablation margin zero, ablation margin（−）, or indeterminate（index tumor was invisible）based on the post-ablation T1WIs and fusion images. The minimal ablation margin was measured and clinical factors were investigated to identify other risk factors for LTP, which was observed in 14 tumors. The mean minimal ablation margin was 1.9mm, excluding 5 indeterminate nodules without LTP, and 8 ablation margin-zero HCCs with LTP, with multivariate logistic regression analysis showing that the likelihood of ablation margin＋was inversely proportional to tumor size. The independent risk factors for LTP were not identified, but the cumulative LTP rates（0％ at 1, 2, and 3 years）in 41 ablation margin＋ nodules were significantly lower（P＝0.005）than those（8.8％, 17.6％, and 17.6％ at 1, 2, and 3 years, respectively）in 34 ablation margin-zero nodules. In conclusion, fusion images might show an early therapeutic response of the ablated tumors in the majority of HCC cases. |
| DOI |
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関連タイプ |
isIdenticalTo |
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関連識別子 |
10.15369/sujms.31.339 |
| 出版者 |
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出版者 |
Showa University Society |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0915-6380 |
| 出版タイプ |
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出版タイプ |
VoR |
S31_339.pdf (776.6 kB)
