WEKO3
アイテム
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EGFR-TKI Versus Chemotherapy for Previously Untreated Advanced Non-Small Cell Lung Cancer in Asians: A Meta-Analysis
https://showa.repo.nii.ac.jp/records/498
https://showa.repo.nii.ac.jp/records/49815649c61-bbf0-4347-b8d5-2fbc401ee8b8
名前 / ファイル | ライセンス | アクション |
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S29_435.pdf (464.6 kB)
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Item type | 学内発行雑誌 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2018-04-20 | |||||
タイトル | ||||||
タイトル | EGFR-TKI Versus Chemotherapy for Previously Untreated Advanced Non-Small Cell Lung Cancer in Asians: A Meta-Analysis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | departmental bulletin paper | |||||
著者 |
ANDO, Koichi
× ANDO, Koichi× KUSUMOTO, Sojiro× TANAKA, Akihiko× YAMAOKA, Toshimitsu× OHMORI, Tohru× OHNISHI, Tsukasa× INOUE, Shin× SAGARA, Hironori |
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書誌情報 |
The Showa University journal of medical sciences 巻 29, 号 4, p. 435-443, 発行日 2017-12 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We comparatively assessed the overall efficacies of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) and chemotherapy for previously untreated, EGFR mutation-positive, advanced non-small cell lung cancer in Asians through a meta-analysis of relevant phase-3 trials. The primary and secondary outcomes were overall survival (OS) and progression-free survival (PFS), respectively. Pooled estimates were calculated as hazard ratios (HRs) with 95% confidence intervals (CIs). Seven studies on EGFR-TKIs met the inclusion criteria for this study. The HRs and 95% CIs for OS and PFS for EGFR-TKIs, relative to chemotherapy, were 0.98 (0.77–1.24) and 0.32 (0.24–0.43), respectively. We found no difference in overall efficacy between EGFR-TKIs and chemotherapy in terms of OS, although the median PFS with EGFR-TKI was superior to that with chemotherapy among Asians with previously untreated, EGFR mutation-positive, advanced non-small cell lung cancer (UMIN ID: UMIN28424). | |||||
DOI | ||||||
関連識別子 | 10.15369/sujms.29.435 | |||||
出版者 | ||||||
出版者 | Showa University Society | |||||
ISSN | ||||||
収録物識別子 | 0915-6380 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |