{"created":"2023-05-15T11:21:50.196126+00:00","id":498,"links":{},"metadata":{"_buckets":{"deposit":"e64e0f26-23f7-4456-9cb6-75c006e29d4d"},"_deposit":{"created_by":1,"id":"498","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"498"},"status":"published"},"_oai":{"id":"oai:showa.repo.nii.ac.jp:00000498","sets":["1:51:59:63"]},"author_link":["2397","2399","2404","2401","2402","2400","2403","2398"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-12"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"443","bibliographicPageStart":"435","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"The Showa University journal of medical sciences"}]}]},"item_10002_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We comparatively assessed the overall efficacies of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) and chemotherapy for previously untreated, EGFR mutation-positive, advanced non-small cell lung cancer in Asians through a meta-analysis of relevant phase-3 trials. The primary and secondary outcomes were overall survival (OS) and progression-free survival (PFS), respectively. Pooled estimates were calculated as hazard ratios (HRs) with 95% confidence intervals (CIs). Seven studies on EGFR-TKIs met the inclusion criteria for this study. The HRs and 95% CIs for OS and PFS for EGFR-TKIs, relative to chemotherapy, were 0.98 (0.77–1.24) and 0.32 (0.24–0.43), respectively. We found no difference in overall efficacy between EGFR-TKIs and chemotherapy in terms of OS, although the median PFS with EGFR-TKI was superior to that with chemotherapy among Asians with previously untreated, EGFR mutation-positive, advanced non-small cell lung cancer (UMIN ID: UMIN28424).\n","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Showa University Society"}]},"item_10002_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.15369/sujms.29.435"}}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0915-6380 "}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ANDO, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KUSUMOTO, Sojiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TANAKA, Akihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMAOKA, Toshimitsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OHMORI, Tohru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OHNISHI, Tsukasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"INOUE, Shin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAGARA, Hironori"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-26"}],"displaytype":"detail","filename":"S29_435.pdf","filesize":[{"value":"464.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S29_435.pdf","url":"https://showa.repo.nii.ac.jp/record/498/files/S29_435.pdf"},"version_id":"14bc138d-c909-4af0-b47b-1d5c49e848d6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"EGFR-TKI Versus Chemotherapy for Previously Untreated Advanced Non-Small Cell Lung Cancer in Asians: A Meta-Analysis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"EGFR-TKI Versus Chemotherapy for Previously Untreated Advanced Non-Small Cell Lung Cancer in Asians: A Meta-Analysis"}]},"item_type_id":"10002","owner":"1","path":["63"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-20"},"publish_date":"2018-04-20","publish_status":"0","recid":"498","relation_version_is_last":true,"title":["EGFR-TKI Versus Chemotherapy for Previously Untreated Advanced Non-Small Cell Lung Cancer in Asians: A Meta-Analysis"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-05-15T12:45:14.899234+00:00"}