| Item type |
学内発行雑誌 / Departmental Bulletin Paper(1) |
| 公開日 |
2016-12-16 |
| タイトル |
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タイトル |
Clinicopathological Study of Intracholecystic Papillary-Tubular Neoplasms (ICPNs) of the Gallbladder |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
departmental bulletin paper |
| 著者 |
ISOZAKI, Masayuki
OHIKE, Nobuyuki
TAJIRI, Takuma
MITSUYA, Toshiyuki
TAKIMOTO, Masafumi
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| 書誌情報 |
The Showa University journal of medical sciences
巻 26,
号 1,
p. 17-26,
発行日 2014-03
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Intracholecystic papillary-tubular neoplasm (ICPN) has recently been proposed as a new disease concept in the classification of gallbladder tumors. ICPN is defined as a papillary or polypoid glandular neoplasm forming a localized, non-invasive mass (≥ 1cm) in the gallbladder. We analyzed the clinicopathological characteristics of ICPN. Resected gallbladder cancer specimens from 57 patients were classified as ICPN or non-ICPN and clinicopathological characteristics were compared. ICPN cell characteristics were also analyzed using immunostaining and genetic analysis. Twenty-three cases were classified as ICPN and 34 as non-ICPN. In the ICPN and non-ICPN groups, mean ages were 69 and 74 years, male:female ratios were 14:9 and 15:19, mean tumor diameters were 2.8 and 2.6cm, invasion depths were Tis+T1/T2+T3 in 14/9 cases and 13/21 cases, lymph node metastases were present in 6% and 43%, distant metastases in 0% and 6% and 3-year survival rates were 91% and 52%, respectively. Significant intergroup differences were seen in lymph node metastases and the 3-year survival rate. ICPN cell lineage was biliary-type in 13 cases, gastric-type in 8 and intestinal-type in 2. This proportion differs from that of pancreatic intraductal papillary mucinous neoplasm (IPMN), in which gastric- and intestinal-type are more common. KRAS gene mutations were only seen in 1 of 13 ICPN cases. ICPN is frequently seen in gallbladder cancer, showing similar pathology to pancreatic IPMN, which is considered to have a relatively good prognosis among pancreatic cancers. However, ICPN cell characteristics are not necessarily identical to those of pancreatic IPMN. |
| DOI |
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関連タイプ |
isIdenticalTo |
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関連識別子 |
10.15369/sujms.26.17 |
| 出版者 |
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出版者 |
Showa University Society |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0915-6380 |
| 出版タイプ |
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出版タイプ |
VoR |
S26_17.pdf (480.9 kB)
