{"created":"2023-05-15T11:21:57.498331+00:00","id":620,"links":{},"metadata":{"_buckets":{"deposit":"29e09d3e-24ea-4f6c-888c-57fe2fe48e15"},"_deposit":{"created_by":1,"id":"620","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"620"},"status":"published"},"_oai":{"id":"oai:showa.repo.nii.ac.jp:00000620","sets":["1:51:74:75"]},"author_link":["3399","3398","3396","3400","3397"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"26","bibliographicPageStart":"17","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"The Showa University journal of medical sciences"}]}]},"item_10002_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Intracholecystic papillary-tubular neoplasm (ICPN) has recently been proposed as a new disease concept in the classification of gallbladder tumors. ICPN is defined as a papillary or polypoid glandular neoplasm forming a localized, non-invasive mass (≥  1cm) in the gallbladder. We analyzed the clinicopathological characteristics of ICPN. Resected gallbladder cancer specimens from 57 patients were classified as ICPN or non-ICPN and clinicopathological characteristics were compared. ICPN cell characteristics were also analyzed using immunostaining and genetic analysis. Twenty-three cases were classified as ICPN and 34 as non-ICPN. In the ICPN and non-ICPN groups, mean ages were 69 and 74 years, male:female ratios were 14:9 and 15:19, mean tumor diameters were 2.8 and 2.6cm, invasion depths were Tis+T1/T2+T3 in 14/9 cases and 13/21 cases, lymph node metastases were present in 6% and 43%, distant metastases in 0% and 6% and 3-year survival rates were 91% and 52%, respectively. Significant intergroup differences were seen in lymph node metastases and the 3-year survival rate. ICPN cell lineage was biliary-type in 13 cases, gastric-type in 8 and intestinal-type in 2. This proportion differs from that of pancreatic intraductal papillary mucinous neoplasm (IPMN), in which gastric- and intestinal-type are more common. KRAS gene mutations were only seen in 1 of 13 ICPN cases. ICPN is frequently seen in gallbladder cancer, showing similar pathology to pancreatic IPMN, which is considered to have a relatively good prognosis among pancreatic cancers. However, ICPN cell characteristics are not necessarily identical to those of pancreatic IPMN.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Showa University Society"}]},"item_10002_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.15369/sujms.26.17"}}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0915-6380"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ISOZAKI, Masayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OHIKE, Nobuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAJIRI, Takuma"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MITSUYA, Toshiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKIMOTO, Masafumi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-26"}],"displaytype":"detail","filename":"S26_17.pdf","filesize":[{"value":"480.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S26_17.pdf","url":"https://showa.repo.nii.ac.jp/record/620/files/S26_17.pdf"},"version_id":"bf538036-c256-47b5-97c9-84786e2d7f5e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"Clinicopathological Study of Intracholecystic Papillary-Tubular Neoplasms (ICPNs) of the Gallbladder","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinicopathological Study of Intracholecystic Papillary-Tubular Neoplasms (ICPNs) of the Gallbladder"}]},"item_type_id":"10002","owner":"1","path":["75"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-12-16"},"publish_date":"2016-12-16","publish_status":"0","recid":"620","relation_version_is_last":true,"title":["Clinicopathological Study of Intracholecystic Papillary-Tubular Neoplasms (ICPNs) of the Gallbladder"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-05-15T12:40:41.463441+00:00"}