{"created":"2023-05-15T11:22:05.696048+00:00","id":747,"links":{},"metadata":{"_buckets":{"deposit":"87af9f89-cdac-4e4a-9d16-52d83c029293"},"_deposit":{"created_by":1,"id":"747","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"747"},"status":"published"},"_oai":{"id":"oai:showa.repo.nii.ac.jp:00000747","sets":["1:51:94:95"]},"author_link":["4354","4355","4360","4357","4358","4359","4356"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"50","bibliographicPageStart":"41","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"The Showa University journal of medical sciences"}]}]},"item_10002_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study investigated the effect of N-[2- (2-oxo-1-imidazolidinyl) ethyl]-N-phenylurea (ethylene diurea, EDU) on oxygen-induced ischemic retinopathy (OIR) in a neonatal rat model. OIR was induced by maintaining daily cycles of 80% oxygen (20.5h), ambient air (0.5h), and a progressive return to 80% oxygen (3h) for 12 days (postnatal day: P12). The rats were treated intraperitoneally with EDU (30mg/kg body weight) or distilled water (DW) from P6 to P17. At P18, the percentage of avascular areas in the total retinal area (%AVA) was measured, and retinal neovascularization (NV) was scored in ADPase-stained retinas. Retinal superoxide dismutase (SOD) activity in the retina was also determined by a chemiluminescence method. The mean %AVA in the EDU-treated group (9.3 ± 1.7%, n = 16) was lower than in the DW group (18.2 ± 4.7%, n = 17). EDU did not significantly affect NV, but significantly increased SOD activity (1.36 ± 0.13 units/mg protein, n = 4) compared to DW treatment (1.04 ± 0.01 units/mg protein, n = 4, P = 0.032) at P18. These results suggest that EDU treatment decreased the %AVA, accompanied by an increase in normal retinal vascular growth and/or a decrease in vessel proliferation. The increased SOD activity observed in the present study is likely to involve the EDU-mediated effects.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Showa Medical Association and Showa University"}]},"item_10002_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.15369/sujms.22.41"}}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0915-6380"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TOMOYASU-OKAMOTO, Sachiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKANISHI-UEDA, Takako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAITO, Yuta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"UEDA, Toshihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YASUHARA, Hajime"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOIDE, Ryohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MOUSA, Shaker A."}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-26"}],"displaytype":"detail","filename":"S22_41.pdf","filesize":[{"value":"360.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S22_41.pdf","url":"https://showa.repo.nii.ac.jp/record/747/files/S22_41.pdf"},"version_id":"8e9a00f0-e488-4a1e-94f5-ea403820917d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"Effect of Ethylene Diurea on Oxygen-induced Ischemic Retinopathy in the Neonatal Rat","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of Ethylene Diurea on Oxygen-induced Ischemic Retinopathy in the Neonatal Rat"}]},"item_type_id":"10002","owner":"1","path":["95"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-12-20"},"publish_date":"2016-12-20","publish_status":"0","recid":"747","relation_version_is_last":true,"title":["Effect of Ethylene Diurea on Oxygen-induced Ischemic Retinopathy in the Neonatal Rat"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-05-15T12:36:35.633671+00:00"}