@article{oai:showa.repo.nii.ac.jp:00000726,
 author = {SAIKI, Makoto and HIROSE, Masanori and SUYAMA, Jumpei and OHGIYA, Yoshimitsu and GOKAN, Takehiko},
 issue = {4},
 journal = {The Showa University journal of medical sciences},
 month = {2010-12, 2019-07-26},
 note = {1H-MR spectroscopy (MRS) of the breast demonstrated that choline could be detected in breast cancers. The purpose of this study was to evaluate the detectability of the choline peak (Tcho) in breast cancer using a 3.0T imager. A total of 52 female patients who underwent MR imaging were evaluated. Localization methods included the SVS and PRESS, with acquisition times of approximately 5 minutes. Correlations among tumor size, histological type, and the presence of Tcho were evaluated. Of 52 breast lesions that were pathologically diagnosed, 50 were malignant [45 invasive ductal carcinomas (IDC), five ductal carcinomas in situ (DCIS) ]and 2 were benign. The presence of Tcho was evaluated in 50 cases. The average diameter of malignant tumors was 2.2 cm and that of benign tumors was 1.9cm. Tcho was identified in 24 of 48 breast cancers (sensitivity 50%, specificity 100%). There was a significant difference between the identification in tumors according to tumor size. Tcho was identified in 76.9% of IDC cases with a diameter greater than the voxel size (1.5cm), while it was identified in only 17.6% of tumors less than 1.5cm in size. Tcho was identified in approximately 77% of breast cancer tumors overall with a diameter greater than the voxel size. The result was comparable with the detectability at 1.5T, although the acquisition times at 3.0T were much shorter than at 1.5T. The advantages at 3.0T include the ability to investigate smaller lesions within a shorter time frame.},
 pages = {221--227},
 title = {Proton (1H) MR Spectroscopy of the Breast at 3.0T: Detectability of the Choline Peak of Breast Cancer in Comparison with a 1.5T Imager},
 volume = {22},
 year = {}
}