{"created":"2023-05-15T11:22:01.330131+00:00","id":682,"links":{},"metadata":{"_buckets":{"deposit":"7d696dda-cd8c-43f3-b928-022e5476e9df"},"_deposit":{"created_by":1,"id":"682","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"682"},"status":"published"},"_oai":{"id":"oai:showa.repo.nii.ac.jp:00000682","sets":["1:51:84:86"]},"author_link":["3881","3883","3882","3885","3888","3884","3880","3887","3886"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-06"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"137","bibliographicPageStart":"127","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"The Showa University journal of medical sciences"}]}]},"item_10002_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Interleukin (IL)-4 exhibits strong antitumor effects and IL-4 gene therapy has been used clinically in the treatment of some types of cancer. In the present study, we evaluated the efficacy of IL-4-transduced tumor cell vaccines in combination with blockade of programmed cell death 1 (PD-1) and investigated the mechanisms underlying the antitumor effects of this therapy. A poorly immunogenic murine colorectal cancer cell line (i.e. MC38) was transduced to overexpress IL-4. In a therapeutic model, MC38-IL4 cells and anti-PD-1 antagonistic antibodies (Ab) were inoculated into parental tumor-bearing mice. Immunohistochemical analyses and tumor-specific lysis were also performed. Additive antitumor effects were observed when mice were treated with IL-4 in combination with an anti-PD-1 Ab. Immunohistochemical analysis of the therapeutic model showed marked infiltration of CD4+ and CD8+ cells into established MC38 tumors of mice treated with anti-PD-1 Ab. Significant tumor-specific cytolysis was detected when the splenocytes of mice treated with both IL-4 and anti-PD-1 Ab were used as effector cells. These results suggest that blockade of the interaction between PD-1 and programmed death ligand 1 (PD-L1) enhances the antitumor immune responses induced by IL-4. Thus, IL-4 gene-transduced tumor cell vaccines in combination with PD-1 blockade may be considered as possible candidates for clinical trials of new cancer vaccines.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Showa Medical Association and Showa University"}]},"item_10002_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.15369/sujms.24.127"}}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0915-6380"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"OMORI, Risa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"EGUCHI, Junichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HIROISHI, Kazumasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ISHII, Shigeaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SASAGAWA, Ayako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAKAKI, Masashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"DOI, Hiroyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAJIWARA, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IMAWARI, Michio"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-26"}],"displaytype":"detail","filename":"S24_127.pdf","filesize":[{"value":"256.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S24_127.pdf","url":"https://showa.repo.nii.ac.jp/record/682/files/S24_127.pdf"},"version_id":"295c9f8b-f047-48d5-ad51-14ed6065e976"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"Effects of Interleukin-4-Transduced Tumor Cell Vaccines and Blockade of Programmed Cell Death 1 on the Growth of Established Tumors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Interleukin-4-Transduced Tumor Cell Vaccines and Blockade of Programmed Cell Death 1 on the Growth of Established Tumors"}]},"item_type_id":"10002","owner":"1","path":["86"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-11-28"},"publish_date":"2016-11-28","publish_status":"0","recid":"682","relation_version_is_last":true,"title":["Effects of Interleukin-4-Transduced Tumor Cell Vaccines and Blockade of Programmed Cell Death 1 on the Growth of Established Tumors"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-05-15T12:38:34.535067+00:00"}