@article{oai:showa.repo.nii.ac.jp:00000630,
 author = {KOBAYASHI, Yusuke and SASAKI, Akiko and TSUJI, Mayumi and UDAKA, Yuko and OYAMADA, Hideto and TSUNODA, Yuko and IWAI, Shinichi and SOMEI, Masayuki and KIZAKI, Junichiro and KONDO, Yasuyuki and SHIMIZU, Katsuyoshi and MIZUTANI, Tohru},
 issue = {4},
 journal = {The Showa University journal of medical sciences},
 month = {2013-12, 2019-07-26},
 note = {Glioblastoma (GBM) is difficult to completely cure by surgical treatment alone, and it is generally treated with a combination of surgery, radiotherapy, and chemotherapy. However, GBM is resistant to radiotherapy and chemotherapy, and complete cure cannot be achieved. Cancer stem cells (CSC) and survivin, which inhibit apoptosis, are considered as factors underlying tumor recurrence and the radiation- and drug-resistance of these tumors. We analyzed CSC and survivin expression in surgically excised specimens of malignant brain tumors to establish the relationships between the grades and CSC and survivin expression and between MIB-1 (Ki-67) expression and resistance. No relationship was noted between the grades and CSC or survivin expression, or between MIB-1 and CSC expression or between Grade 3 and 4 MIB-1 and survivin expression, although a correlation was noted between MIB-1 and survivin expression in Grade II tumors. These findings suggested that CSC are consistently contained in tumor tissue at a specific rate regardless of the histological grade, and the apoptosis of cells with low-level proliferative and cell cycling activities does not occur because these cells do not respond to chemotherapy or radiation, being resistant to treatment.},
 pages = {255--262},
 title = {Relationship of Grade of Malignant Brain Tumor to Cancer Stem Cells and Survivin Expression},
 volume = {25},
 year = {}
}