{"created":"2023-05-15T11:21:53.662433+00:00","id":554,"links":{},"metadata":{"_buckets":{"deposit":"fa42df8e-4304-4561-98c1-4d538131a911"},"_deposit":{"created_by":1,"id":"554","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"554"},"status":"published"},"_oai":{"id":"oai:showa.repo.nii.ac.jp:00000554","sets":["1:51:64:66"]},"author_link":["2869","2870","2875","2873","2877","2874","2876","2871","2872"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"181","bibliographicPageStart":"173","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"The Showa University journal of medical sciences"}]}]},"item_10002_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Psoriasis is a chronic immune-mediated disease in which the interleukin (IL)-23/IL-17 axis plays a key role in the inflammatory cascade. We recently reported that co-expression of CCR6 and melanoma cell adhesion molecule (MCAM) in effector memory CD4 T cells (TEM) of peripheral blood might be a useful marker for T helper (Th) 17 cells. In this study, we monitored changes in TEM expressing CCR6 and MCAM using the Psoriasis Area and Severity Index (PASI) score during anti-tumor necrosis factor (TNF) therapy. We also studied CCR6+ MCAM+ Th17 cells histologically in skin biopsy samples from psoriasis patients. In psoriasis patients treated with anti-TNF therapy, the PASI score and the percentage of CCR6+ MCAM+ TEM cells in the blood changed almost in parallel. In immunohistochemical analyses, the proportions of IL-17+ T cells and MCAM+ T cells in the lesional skin of severely psoriatic patients were significantly higher than in mildly psoriatic patients (P<0.05), and the number of IL17+ T cells correlated with the PASI score (r=0.400, P<0.05). Taken together, these results indicate that CCR6+ MCAM+ Th17 cells in peripheral blood and lesional skin might play an important role in the pathology of psoriasis.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Showa University Society"}]},"item_10002_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.15369/sujms.28.173"}}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0915-6380 "}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KOBAYASHI, Kae"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"WATANABE, Hideaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAMIYAMA, Taisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SUEKI, Hirohiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SASAKI, Yosuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMOCHI, Toshiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOKAZE, Akatsuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IWAMOTO, Sanju"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKIMOTO, Masafumi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-26"}],"displaytype":"detail","filename":"S28_173.pdf","filesize":[{"value":"4.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S28_173.pdf","url":"https://showa.repo.nii.ac.jp/record/554/files/S28_173.pdf"},"version_id":"5b2ff872-6143-417d-b3af-62387f322d30"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"CCR6+ MCAM+ Th17 Cell Numbers Increase in Patients with Psoriasis and Correlate with Disease Severity ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CCR6+ MCAM+ Th17 Cell Numbers Increase in Patients with Psoriasis and Correlate with Disease Severity "}]},"item_type_id":"10002","owner":"1","path":["66"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-12-27"},"publish_date":"2018-12-27","publish_status":"0","recid":"554","relation_version_is_last":true,"title":["CCR6+ MCAM+ Th17 Cell Numbers Increase in Patients with Psoriasis and Correlate with Disease Severity "],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-05-15T12:43:17.291551+00:00"}