{"created":"2023-05-15T11:21:52.391605+00:00","id":533,"links":{},"metadata":{"_buckets":{"deposit":"b3d125e0-4bbf-4217-862e-66db772e9ff7"},"_deposit":{"created_by":1,"id":"533","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"533"},"status":"published"},"_oai":{"id":"oai:showa.repo.nii.ac.jp:00000533","sets":["1:51:64:68"]},"author_link":["2695","2697","2694","2698","2699","2696"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-12"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"347","bibliographicPageStart":"337","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"The Showa University journal of medical sciences"}]}]},"item_10002_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of the present study was to assess the non-inferiority of low-dose benralizumab relative to high-dose benralizumab as a treatment option for uncontrolled eosinophilic asthma through a meta-analysis of efficacy and safety in randomized controlled trials (RCTs). PubMed, the Cochrane Library Database, and Scopus were searched to identify relevant articles. Outcome measures were a change in the Asthma Control Questionnaire-6 (ACQ-6) score and the exacerbation rate. In addition, the meta-analysis assessed the incidence of adverse events, injection site reactions, and pyrexia or influenza-like illness. Two RCTs with two doses of benralizumab (20 and 100mg) and a placebo for the treatment of uncontrolled eosinophilic asthma met the criteria and were included in the present study. Non-inferiority of low-dose (20mg) versus high-dose (100mg) benralizumab was shown for the change in ACQ-6 score, exacerbation rate, and the incidence of adverse events, injection site reactions, and pyrexia or influenza-like illness. Although not significant, the incidence of pyrexia or influenza-like illness was lower in patients treated with low-dose benralizumab. These results suggest that low-dose (20mg) benralizumab is effective for symptom control and reduction of exacerbation rate in uncontrolled eosinophilic asthma, with lower treatment costs.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Showa University Society"}]},"item_10002_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.15369/sujms.28.337"}}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0915-6380 "}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ANDO, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TANAKA, Akihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YOKOE, Takuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OHNISHI, Tsukasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"INOUE, Shin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAGARA, Hironori"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-26"}],"displaytype":"detail","filename":"S28_337.pdf","filesize":[{"value":"456.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S28_337.pdf","url":"https://showa.repo.nii.ac.jp/record/533/files/S28_337.pdf"},"version_id":"9d40f2cc-eab6-44b3-b3f0-4da6ffa75100"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"Meta-analysis of Low-versus High-dose Benralizumab in Adults with Uncontrolled Eosinophilic Asthma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Meta-analysis of Low-versus High-dose Benralizumab in Adults with Uncontrolled Eosinophilic Asthma"}]},"item_type_id":"10002","owner":"1","path":["68"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-01"},"publish_date":"2017-12-01","publish_status":"0","recid":"533","relation_version_is_last":true,"title":["Meta-analysis of Low-versus High-dose Benralizumab in Adults with Uncontrolled Eosinophilic Asthma"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-05-15T12:44:03.332258+00:00"}