{"created":"2023-05-15T11:21:49.225840+00:00","id":481,"links":{},"metadata":{"_buckets":{"deposit":"7856905e-77c8-4814-af30-b81ecf4ea544"},"_deposit":{"created_by":1,"id":"481","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"481"},"status":"published"},"_oai":{"id":"oai:showa.repo.nii.ac.jp:00000481","sets":["1:51:56:57"]},"author_link":["2293","2292","2289","2294","2288","2290","2287","2291"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"52","bibliographicPageStart":"43","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"The Showa University journal of medical sciences"}]}]},"item_10002_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The present study sought to compare the effectiveness of a proton pump inhibitor （PPI） with that of a histamine H2 receptor antagonist （H2RA） for treating functional dyspepsia （FD） in a real-world setting. A multicenter, open-label, randomized trial was conducted. FD patients were randomly assigned to receive either 20mg, q.d., omeprazole （OPZ; a PPI） or 150mg, b.i.d., ranitidine hydrochloride （RAN; an H2RA） for 4 weeks. Any change in the total Gastrointestinal Symptom Rating Scale （GSRS） score （delta） at week 4 was the primary outcome measure. Secondary outcome measures were reductions in scores for individual items on the GSRS at week 4. As a subanalysis, patients were stratified according to Helicobacter pylori serology and the analyses were repeated. The mean （±SD） deltas in total GSRS score for the OPZ and RAN groups were 0.8±0.7 and 0.6±0.6, respectively （P＝0.098）; however, the delta in reflux score between the OPZ and RAN groups differed significantly （1.1±0.7 vs. 0.5±0.5, respectively; P＝0.001）. There were no significant differences between the two groups in any other scores for individual items on the GSRS. The results of the subanalysis were like those of the main analysis. The PPI and H2RA produced a comparable improvement in symptoms of FD in our patient cohort, thus we propose no advantage would be gained in using a PPI rather than an H2RA.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Showa University Society"}]},"item_10002_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.15369/sujms.30.43"}}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0915-6380 "}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TASHIRO, Tomoe"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKEUCHI, Yoshiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAKURAI, Yukihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ARAI, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHIBATA, MinorI"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAZAKI, Shuhei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NISHIKAWA, Junichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YOSHIDA, Hitoshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-26"}],"displaytype":"detail","filename":"S30_43.pdf","filesize":[{"value":"109.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S30_43.pdf","url":"https://showa.repo.nii.ac.jp/record/481/files/S30_43.pdf"},"version_id":"454aa7ba-5e0f-41ea-b715-429059bcd3bc"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"Comparative Study of a Proton Pump Inhibitor with a Histamine H2 Receptor Antagonist in Japanese Patients with Functional Dyspepsia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparative Study of a Proton Pump Inhibitor with a Histamine H2 Receptor Antagonist in Japanese Patients with Functional Dyspepsia"}]},"item_type_id":"10002","owner":"1","path":["57"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-08-23"},"publish_date":"2018-08-23","publish_status":"0","recid":"481","relation_version_is_last":true,"title":["Comparative Study of a Proton Pump Inhibitor with a Histamine H2 Receptor Antagonist in Japanese Patients with Functional Dyspepsia"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-05-15T12:45:49.513519+00:00"}