{"created":"2023-05-15T11:21:48.809561+00:00","id":475,"links":{},"metadata":{"_buckets":{"deposit":"eea38833-1e60-4ed0-9abb-0388271ccb4f"},"_deposit":{"created_by":1,"id":"475","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"475"},"status":"published"},"_oai":{"id":"oai:showa.repo.nii.ac.jp:00000475","sets":["1:51:56:58"]},"author_link":["2250","2249","2251","2248","2247"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"307","bibliographicPageStart":"297","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"The Showa University journal of medical sciences"}]}]},"item_10002_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The overall efficacy of therapeutic monoclonal antibodies （mAbs） for asthma control in patients with uncontrolled eosinophilic asthma remains to be fully characterized. We conducted a meta-analysis of randomized controlled trials （RCTs） to analyze the efficacies of new therapeutic mAbs, such as anti-interleukin （IL）-13 therapies, anti-IL4/13 therapies, and anti-IL-5 therapies, compared with that of a placebo in patients with uncontrolled asthma. This meta-analysis complies with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses （PRISMA） guidelines. The primary efficacy outcome was asthma control as assessed by Asthma Control Questionnaire （ACQ） scores. Pooled estimates are presented as standardized mean differences （Std MDs） with 95% confidence intervals （CIs）. Seven RCTs of therapeutic mAbs, including anti-IL-13, anti-IL-4/13, and anti-IL-5, met the criteria for study inclusion. The overall Std MD of changes in the ACQ score was −0.31 （95% CI, −0.45 to −0.17; P＜0.0001）. These results strongly indicate that therapeutic mAbs are effective in controlling asthma in patients with uncontrolled eosinophilic asthma.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Showa University Society"}]},"item_10002_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.15369/sujms.30.297"}}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0915-6380 "}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ANDO, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TANAKA, Akihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OHNISHI, Tsukasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"INOUE, Shin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAGARA, Hironori"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-26"}],"displaytype":"detail","filename":"S30_297.pdf","filesize":[{"value":"546.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S30_297.pdf","url":"https://showa.repo.nii.ac.jp/record/475/files/S30_297.pdf"},"version_id":"692a41f6-49b3-4935-a219-afce5b33cb2a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"Effectiveness of Therapeutic Monoclonal Antibodies for Asthma Control in Uncontrolled Eosinophilic Asthma-A Meta-analysis of Randomized Controlled Trials-","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effectiveness of Therapeutic Monoclonal Antibodies for Asthma Control in Uncontrolled Eosinophilic Asthma-A Meta-analysis of Randomized Controlled Trials-"}]},"item_type_id":"10002","owner":"1","path":["58"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-09-03"},"publish_date":"2018-09-03","publish_status":"0","recid":"475","relation_version_is_last":true,"title":["Effectiveness of Therapeutic Monoclonal Antibodies for Asthma Control in Uncontrolled Eosinophilic Asthma-A Meta-analysis of Randomized Controlled Trials-"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-05-15T12:45:59.531714+00:00"}