{"created":"2023-05-15T11:24:06.868604+00:00","id":3839,"links":{},"metadata":{"_buckets":{"deposit":"e8ba6e8b-9a88-4db0-9bda-a37bfc7ef1b5"},"_deposit":{"created_by":1,"id":"3839","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"3839"},"status":"published"},"_oai":{"id":"oai:showa.repo.nii.ac.jp:00003839","sets":["1:51:308:336"]},"author_link":["12888","12889","12886","12887"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"73","bibliographicPageStart":"67","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"The Showa University journal of medical sciences"}]}]},"item_10002_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Monocyte-derived Langerhans cell-like dendritic cells （Mo-LCs） are involved in epidermal disorders such as psoriasis in murine models. However, the roles of Mo-LCs in the pathogenesis of psoriasis in humans remain unclear. Also, the contribution of notch ligand delta-like 1 （DLL-1）, expressed on keratinocytes, to Mo-LC functions requires clarification. Here, we established a new method of stimulating Mo-LCs derived from CD14＋ monocytes with immobilized human DLL-1 to generate induced Mo-LCs （DI（＋）Mo-LCs）. The DI（＋）Mo-LCs were compared to the dendritic cells derived from monocytes （Mo-DCs） cultured with interleukin-4 （IL-4） and granulocyte-macrophage colony-stimulating factor （GM-CSF）, and M1 macrophages （Mφ） derived from monocytes cultured with GM-CSF. The DI（＋）Mo-LCs were found to produce significant amounts of IL15, IL23A, and interferon-β （IFNB1） in response to the Toll-like receptor （TLR）3 agonist Polyinosinic-polycytidylic acid （Poly（I:C）） or TLR4 agonist lipopolysaccharide （LPS） despite their low expression of tumor necrosis factor （TNF）. In conclusion, we have established a new method to generate DI（＋）Mo-LCs. We have also discovered that DI（＋）Mo-LCs have a unique capacity for producing IL15 and IL23A, which are related to the pathogenesis of psoriasis. Our data contribute to a better understanding of the roles of Mo-LCs in epidermal defense and pathogenesis.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Showa University Society"}]},"item_10002_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.15369/sujms.33.67"}}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2185-0968"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TAKAHASHI, Rei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IWAMOTO, Sanju"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TANIOKA, Toshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MAEDA, Kohei"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-09-22"}],"displaytype":"detail","filename":"S33_67.pdf","filesize":[{"value":"386.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S33_67.pdf","url":"https://showa.repo.nii.ac.jp/record/3839/files/S33_67.pdf"},"version_id":"f4ba1563-71e3-4bf4-80fa-b708d22b9ff6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"A profile of pro-inflammatory cytokine expression in human Delta-1-induced monocyte-derived Langerhans cell-like dendritic cells after stimulation with Toll-like receptor ligands","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A profile of pro-inflammatory cytokine expression in human Delta-1-induced monocyte-derived Langerhans cell-like dendritic cells after stimulation with Toll-like receptor ligands"}]},"item_type_id":"10002","owner":"1","path":["336"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-09-22"},"publish_date":"2021-09-22","publish_status":"0","recid":"3839","relation_version_is_last":true,"title":["A profile of pro-inflammatory cytokine expression in human Delta-1-induced monocyte-derived Langerhans cell-like dendritic cells after stimulation with Toll-like receptor ligands"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T12:14:50.442677+00:00"}