{"created":"2023-05-15T11:24:06.317471+00:00","id":3831,"links":{},"metadata":{"_buckets":{"deposit":"f2d3bacf-a6de-4e7b-aeaa-05f8ccdac816"},"_deposit":{"created_by":1,"id":"3831","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"3831"},"status":"published"},"_oai":{"id":"oai:showa.repo.nii.ac.jp:00003831","sets":["1:6:312:335"]},"author_link":["12818","12815","12820","12817","12816","12821","12812","12814","12813","12819","12822"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-08"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"241","bibliographicPageStart":"229","bibliographicVolumeNumber":"81","bibliographic_titles":[{"bibliographic_title":"昭和学士会雑誌"}]}]},"item_10002_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"社交不安は自閉症スペクトラム障害（Autism Spectrum Disorder， 以下ASD）の主要な併存症状の一つであるが，その神経解剖学的基盤は未だに十分に研究されていない．本研究では，成人ASDの社交不安の神経解剖学的相関を神経学的定型群（Neurotypical Control，以下NC）と比較して検討した．対象は，昭和大学附属烏山病院の外来患者の内，精神障害者の診断と統計マニュアル第4版改訂版でASDと診断された40名の男性と，健常者43名のNC男性であった．社会統計学的および臨床的特徴を収集し，リーボヴィッツ社交不安尺度日本語版（Liebowitz Social Anxiety Scale，以下LSAS-J），自閉症スペクトラム指数，ウェクスラー知能検査第3版（Wechsler Adult Intelligence Scale, Third Edition，以下WAIS-Ⅲ）を用いて，それぞれ社交不安の重症度，ASD症状，知的プロフィールを評価した．全脳1.5T磁気共鳴画像法（Magnetic Resonance Imaging，以下MRI）スキャンを実施した．LSAS-Jスコアの神経解剖学的相関を調べるために，Voxel-based morphometry（以下VBM）解析を行った．ASD群ではLSAS-Jスコアが左上側頭回および右感覚運動野の灰白質密度（Gray Matter Density，以下GMD）とそれぞれ正と負の相関を示した．一方，NC群ではLSAS-Jスコアが両側前頭極および左被殻のGMDとそれぞれ正と負の相関を示した．関心領域解析を行った結果，上記4領域のうち，左上側頭回以外の右感覚運動野，左前頭極および左被殻における平均GMDはLSAS-Jと群要因の交互作用を認めた．ASD群は，NC群と比較して，社交不安の神経解剖学的相関に特徴があり，おそらく社交不安の高まりに対する代償メカニズムが異なるためであろうと考えられる．このことは，ASDにおける社交不安の特徴を示唆している．","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"昭和大学学士会"}]},"item_10002_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.14930/jshowaunivsoc.81.229"}}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2188-529X"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"澤登, 洋輔"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高塩, 理"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"橋本, 龍一郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"林, 若穂"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小島, 睦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小野, 英里子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"西尾, 崇志"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"青栁, 啓介"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"太田, 晴久"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"板橋, 貴史"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岩波, 明"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-09-15"}],"displaytype":"detail","filename":"81_229.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"81_229.pdf","url":"https://showa.repo.nii.ac.jp/record/3831/files/81_229.pdf"},"version_id":"336ad664-0c18-4975-94ca-9db18c699677"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"自閉症スペクトラム障害における社交不安の神経解剖学的相関：Voxel-Based Morphometryを用いた予備的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"自閉症スペクトラム障害における社交不安の神経解剖学的相関：Voxel-Based Morphometryを用いた予備的研究"}]},"item_type_id":"10002","owner":"1","path":["335"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-09-15"},"publish_date":"2021-09-15","publish_status":"0","recid":"3831","relation_version_is_last":true,"title":["自閉症スペクトラム障害における社交不安の神経解剖学的相関：Voxel-Based Morphometryを用いた予備的研究"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T12:17:31.562519+00:00"}