{"created":"2023-05-15T11:21:39.512311+00:00","id":320,"links":{},"metadata":{"_buckets":{"deposit":"5652e019-90ff-4364-b7c2-1a95e5781eda"},"_deposit":{"created_by":1,"id":"320","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"320"},"status":"published"},"_oai":{"id":"oai:showa.repo.nii.ac.jp:00000320","sets":["1:6:33:39"]},"author_link":["1515","1519","1524","1523","1516","1517","1522","1520","1521","1518"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-12"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"674","bibliographicPageStart":"669","bibliographicVolumeNumber":"74","bibliographic_titles":[{"bibliographic_title":"昭和学士会雑誌"}]}]},"item_10002_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"予後不良のTriple Negative Breast Cancer(TNBC)はホルモン感受性がないために標的治療薬が確立されていない。また近年、TNBCがbasal-like1(BL1)、basal-like2(BL2)、immunomodulatory(IM)、mesenchymal(M)、mesenchymal stem-like(MSL)、luminal androgen receptor(LAR)の6種類に亜分類されたことから、各サブタイプにおける標的ターゲットを確定することが望まれている。今回われわれは乳癌90症例を用いて乳癌の進行度と関連するアクチン結合タンパク質Fascinの発現を解析した。さらにTNBC 22症例についてはbasal like typeとnon-basal like typeに分類しFascinの組織特異的な発現を検討した。乳癌90症例のうちFascin陽性率はLuminal Aで0%、Luminal B(human epidermal growth factor receptor 2(HER2)negative)6%、Luminal B(HER2 positive)14%、HER2 positive(non luminal)13%、TNBCは73%であった。また、TNBC 22症例で臨床病理学的因子との関係ではFascin陽性乳癌はKi-67 indexが30%以上の腫瘤が有意に多く、悪性度の高さが示された。TNBC亜分類のbasal like typeのFascin発現率はnon-basal like typeよりも高かった。以上のことからFascinタンパク質発現とTNBC basal like typeの関係が明らかとなった。FascinはTNBCにおける悪性度や予後予測の新たな診断基準となり、TNBC治療ターゲットになる可能性が示唆された。(著者抄録)","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"昭和大学学士会"}]},"item_10002_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.14930/jshowaunivsoc.74.669"}}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2187-719X"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"外池, 孝彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐々木, 晶子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"土屋, 洋道"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"橋本, 翔太郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"百々, 悠介"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"角田, ゆう子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"瀧本, 雅文"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"九島, 巳樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"澤田, 晃暢"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中村, 清吾"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-26"}],"displaytype":"detail","filename":"74_669.pdf","filesize":[{"value":"372.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"74_669.pdf","url":"https://showa.repo.nii.ac.jp/record/320/files/74_669.pdf"},"version_id":"e77241c4-8355-4761-aa46-0b0a7a8623e7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"乳癌におけるFascinタンパク質発現の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"乳癌におけるFascinタンパク質発現の検討"}]},"item_type_id":"10002","owner":"1","path":["39"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-18"},"publish_date":"2015-11-18","publish_status":"0","recid":"320","relation_version_is_last":true,"title":["乳癌におけるFascinタンパク質発現の検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T13:04:47.821212+00:00"}