{"created":"2023-05-15T11:23:23.777235+00:00","id":2988,"links":{},"metadata":{"_buckets":{"deposit":"c1121ee1-eb84-46a6-9d4b-caf9a0ec3f9a"},"_deposit":{"created_by":1,"id":"2988","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2988"},"status":"published"},"_oai":{"id":"oai:showa.repo.nii.ac.jp:00002988","sets":["1:51:241:242"]},"author_link":["10249","10251","10248","10250","10246","10247"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"39","bibliographicPageStart":"29","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"The Showa University journal of medical sciences"}]}]},"item_10002_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Polypodium leucotomos（PL）is a fern native to Latin America, and its extract is used as an oral sunscreen; however, its safety during use has not been adequately investigated. Therefore, the aim of this study was to evaluate food-drug interactions associated with PL extract mediated by cytochrome P450 3A（CYP3A）inhibition and induction. Inhibition of CYP3A-mediated midazolam（MDZ）1’-hydroxylation activity by PL extract and its major phenolic components was evaluated in vitro using pooled human liver microsomes. In addition, MDZ pharmacokinetics were investigated in rats after a single dose, as well as after 1 week treatment with PL extract（30mg/kg）in order to evaluate the inhibitory and inducible effects of PL on CYP3A in vivo, respectively. Serum MDZ concentrations were analyzed and pharmacokinetic parameters were compared between PL- and water（control）-treated groups. In vitro, PL extract decreased MDZ 1’-hydroxylation activity in a concentration-dependent manner. However, the major phenolic compounds in PL extracts, namely caffeic, chlorogenic, p-coumaric, ferulic, and vanillic acids, did not exhibit any marked inhibitory effects on MDZ 1’-hydroxylation activity. In vivo, administration of a single dose of PL extract to rats significantly increased the area under the serum concentration-time curve from time 0 to infinity（AUC0–∞）and the maximum serum concentration（Cmax）of MDZ（by 57％ and 88％, respectively; P＜0.05）. In contrast, there were no significant changes in MDZ pharmacokinetic parameters after 1 week of treatment with PL extract. These results suggest that PL extract can cause a food-drug interaction by inhibiting CYP3A.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Showa University Society"}]},"item_10002_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.15369/sujms.31.29"}}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0915-6380 "}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"GOMI, Yurika"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NISHIMURA, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KURATA, Norimitsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IWASE Mariko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHINYA, Koichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KIUCHI, Yuji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-09"}],"displaytype":"detail","filename":"S31_29.pdf","filesize":[{"value":"780.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S31_29.pdf","url":"https://showa.repo.nii.ac.jp/record/2988/files/S31_29.pdf"},"version_id":"11454b37-07e9-4d1f-a8af-426faf87df87"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"Inhibitory Effect of Polypodium Leucotomos Extract on Cytochrome P450 3A-mediated Midazolam Metabolism","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibitory Effect of Polypodium Leucotomos Extract on Cytochrome P450 3A-mediated Midazolam Metabolism"}]},"item_type_id":"10002","owner":"1","path":["242"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-08-09"},"publish_date":"2019-08-09","publish_status":"0","recid":"2988","relation_version_is_last":true,"title":["Inhibitory Effect of Polypodium Leucotomos Extract on Cytochrome P450 3A-mediated Midazolam Metabolism"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-05-15T12:46:58.085992+00:00"}