{"created":"2023-05-15T11:22:33.605856+00:00","id":1181,"links":{},"metadata":{"_buckets":{"deposit":"b0ae38cb-4611-4af7-9b18-3b0080987942"},"_deposit":{"created_by":1,"id":"1181","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"1181"},"status":"published"},"_oai":{"id":"oai:showa.repo.nii.ac.jp:00001181","sets":["1:54:148:149"]},"author_link":["6297","6294","6299","6295","6296","6298"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"62","bibliographicPageStart":"53","bibliographicVolumeNumber":"1","bibliographic_titles":[{"bibliographic_title":"昭和大学薬学雑誌"}]}]},"item_10002_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"小胞体に存在する熱ショック蛋白(HSP)47がアディポネクチン(Adipo)のコラーゲン様ドメインに結合してAdipo分泌を制御する可能性について検討した。HEK293細胞にAdipoとHSP47を過剰発現させた細胞を用いて培養上清中に分泌されるAdipo量を測定した。過剰発現細胞におけるHSP47の発現量は対照細胞の約2倍に上昇した。HSP47過剰発現細胞のAdipo分泌量はAdipoを単独発現させた細胞よりも約50%のAdipo分泌の減少を認めた。siRNAを導入したHSP47ノックダウン細胞では、HSP47の発現が対照細胞よりも60%減少した。一方で培養上清中に分泌されるAdipo量は2.8倍と顕著に上昇していた。また、免疫沈降反応により解析した結果、HSP47がAdipoと結合していることを確認した。以上より、小胞体におけるHSP47発現がAdipo分泌経路において重要な役割を果たすと考えられた。","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"昭和大学薬学雑誌編集委員会"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1884-7854"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"谷岡, 利裕"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"野場, 悠司"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"當間, 聡子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大野, 直美"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"戸部, 敞"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中野, 泰子"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-26"}],"displaytype":"detail","filename":"P1_53.pdf","filesize":[{"value":"649.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"P1_53.pdf","url":"https://showa.repo.nii.ac.jp/record/1181/files/P1_53.pdf"},"version_id":"bc693f42-1846-4f17-bb2f-7292a03d9634"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"アディポネクチン分泌はHSP47により制御されている","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アディポネクチン分泌はHSP47により制御されている"}]},"item_type_id":"10002","owner":"1","path":["149"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"1181","relation_version_is_last":true,"title":["アディポネクチン分泌はHSP47により制御されている"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T12:52:02.148939+00:00"}