WEKO3
アイテム
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Effect of Ethylene Diurea on Oxygen-induced Ischemic Retinopathy in the Neonatal Rat
https://showa.repo.nii.ac.jp/records/747
https://showa.repo.nii.ac.jp/records/747a194dd20-1761-4dcc-9a87-d44363ddd2b1
名前 / ファイル | ライセンス | アクション |
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S22_41.pdf (360.9 kB)
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Item type | 学内発行雑誌 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-12-20 | |||||
タイトル | ||||||
タイトル | Effect of Ethylene Diurea on Oxygen-induced Ischemic Retinopathy in the Neonatal Rat | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | departmental bulletin paper | |||||
著者 |
TOMOYASU-OKAMOTO, Sachiko
× TOMOYASU-OKAMOTO, Sachiko× NAKANISHI-UEDA, Takako× SAITO, Yuta× UEDA, Toshihiko× YASUHARA, Hajime× KOIDE, Ryohei× MOUSA, Shaker A. |
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書誌情報 |
The Showa University journal of medical sciences 巻 22, 号 1, p. 41-50, 発行日 2010-03 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | This study investigated the effect of N-[2- (2-oxo-1-imidazolidinyl) ethyl]-N-phenylurea (ethylene diurea, EDU) on oxygen-induced ischemic retinopathy (OIR) in a neonatal rat model. OIR was induced by maintaining daily cycles of 80% oxygen (20.5h), ambient air (0.5h), and a progressive return to 80% oxygen (3h) for 12 days (postnatal day: P12). The rats were treated intraperitoneally with EDU (30mg/kg body weight) or distilled water (DW) from P6 to P17. At P18, the percentage of avascular areas in the total retinal area (%AVA) was measured, and retinal neovascularization (NV) was scored in ADPase-stained retinas. Retinal superoxide dismutase (SOD) activity in the retina was also determined by a chemiluminescence method. The mean %AVA in the EDU-treated group (9.3 ± 1.7%, n = 16) was lower than in the DW group (18.2 ± 4.7%, n = 17). EDU did not significantly affect NV, but significantly increased SOD activity (1.36 ± 0.13 units/mg protein, n = 4) compared to DW treatment (1.04 ± 0.01 units/mg protein, n = 4, P = 0.032) at P18. These results suggest that EDU treatment decreased the %AVA, accompanied by an increase in normal retinal vascular growth and/or a decrease in vessel proliferation. The increased SOD activity observed in the present study is likely to involve the EDU-mediated effects. | |||||
DOI | ||||||
関連識別子 | 10.15369/sujms.22.41 | |||||
出版者 | ||||||
出版者 | Showa Medical Association and Showa University | |||||
ISSN | ||||||
収録物識別子 | 0915-6380 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |