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A Clinicopathological Study of Primary Small Intestinal Cancer with Emphasis on Cellular Characteristics
https://showa.repo.nii.ac.jp/records/666
https://showa.repo.nii.ac.jp/records/6663e6d6161-188f-42c9-9962-4764c3915769
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
S24_309.pdf (450.7 kB)
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| Item type | 学内発行雑誌 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2016-11-24 | |||||
| タイトル | ||||||
| タイトル | A Clinicopathological Study of Primary Small Intestinal Cancer with Emphasis on Cellular Characteristics | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
NOGAKI, Koji
× NOGAKI, Koji× OHIKE, Nobuyuki× TAKAHASHI, Manabu× TSUKUDA, Genki× WADA, Yusuke× HIRABAYASHI, Kodai× KAWAMURA, Yojiro× KUNIMURA, Toshiaki× KUMAGAI, Kazuhide× MURAKAMI, Masahiko× MOROHOSHI, Toshio |
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| 書誌情報 |
The Showa University journal of medical sciences 巻 24, 号 4, p. 309-318, 発行日 2012-12 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We examined the clinicopathological profiles and cellular characteristics of 10 cases of surgically resected primary small intestinal cancers (excluding duodenal cancers). Histological examination revealed nine adenocarcinomas and one sarcomatoid carcinoma. Invasion depth was subserosal in five cases, serosal in four cases and to the adjacent transverse colon in the remaining case. Metastasis was present in lymph node in seven cases, in distant organs in six, and in the peritoneum in seven cases. Of the 10 cases, 7 underwent postoperative chemotherapy, and 6 of the eight traceable patients died from the disease (mean period of survival: 386 days). Histomorphologically, eight of nine adenocarcinomas showed an intestinal phenotype (unclassifiable in the other) in the upper layer, while in the lower layer, there showed an intestinal phenotype and five a non-intestinal phenotyp. Immunohistochemistry revealed a mean positive rate in the upper/lower layers as follows: 93%/86% and 38%/29% by intestinal markers CDX2 and MUC2; 19%/28% and 13%/32% by pancreatobiliary markers CK7 and MUC1; and 4%/19% and 2%/9% by gastric markers MUC5AC and MUC6, respectively. Thus, the intestinal phenotype predominated in almost all small intestinal cancer in this study, although some showed a transformation to non-intestinal or hybrid phenotypes with tumor progression. Flexible management for the diversity and transformation of cellular characteristics is therefore recommended treating and diagnosing small intestinal cancers. | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.15369/sujms.24.309 | |||||
| 出版者 | ||||||
| 出版者 | Showa Medical Association and Showa University | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0915-6380 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
