WEKO3
アイテム
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Immunohistochemical Analysis of Various Salivary Gland Carcinomas Focusing on the Possibility of Molecular-targeted and Hormonal Therapy
https://showa.repo.nii.ac.jp/records/656
https://showa.repo.nii.ac.jp/records/6567cb20558-ed95-4a30-8759-f68f3335bcf3
名前 / ファイル | ライセンス | アクション |
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S25_29.pdf (822.9 kB)
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Item type | 学内発行雑誌 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-11-22 | |||||
タイトル | ||||||
タイトル | Immunohistochemical Analysis of Various Salivary Gland Carcinomas Focusing on the Possibility of Molecular-targeted and Hormonal Therapy | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | departmental bulletin paper | |||||
著者 |
KAWAMURA, Yojiro
× KAWAMURA, Yojiro× KUNIMURA, Toshiaki× OMATSU, Mutsuko× MORI, Tomoaki× SANBE, Takeyuki× MOROHOSHI, Toshio |
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書誌情報 |
The Showa University journal of medical sciences 巻 25, 号 1, p. 29-39, 発行日 2013-03 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | This study aimed to determine the expression of c-kit, human epidermal growth factor receptor type 2 (HER2), insulin-like growth factor receptor (IGFR), estrogen receptor (ER), progesterone receptor (PgR), vascular endothelial growth factor (VEGF), c-MET, and survivin in adenoid cystic carcinomas (ACC), carcinomas ex pleomorphic adenomas (CXPA), and mucoepidermoid carcinomas (MEC) of the salivary glands. These expression levels and locations were compared to estimate the availability of molecular and hormonal targets for therapy in salivary gland carcinomas. Forty patients with a salivary gland carcinoma, diagnosed and treated at our hospital, were studied. On the basis of histopathology, 13, 12, and 15 patients were diagnosed with ACC, CXPA, and MEC, respectively. Associations between histological types were evaluated by Fisher's exact test, with a significance level of P < 0.05. Compared with the other two histological types, ACC samples demonstrated significantly higher c-kit (85%), IGFR (77%), and ER (38%) expression, while CXPA demonstrated significant HER2 (75%) staining, and MEC demonstrated significant IGFR (77%) staining. The differences in expression of the tested markers among the histological types in our study suggested that c-kit- and IGFR-targeted therapy and anti-estrogen treatment could be effective in ACC, HER2-targeted therapy could be effective in CXPA, and that IGFR-target therapy could be effective in MEC of the salivary glands. | |||||
DOI | ||||||
関連識別子 | 10.15369/sujms.25.29 | |||||
出版者 | ||||||
出版者 | Showa University Society | |||||
ISSN | ||||||
収録物識別子 | 0915-6380 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |