WEKO3
アイテム
{"_buckets": {"deposit": "85f1897f-3a50-4421-8ba2-0fc5279faa01"}, "_deposit": {"created_by": 1, "id": "630", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "630"}, "status": "published"}, "_oai": {"id": "oai:showa.repo.nii.ac.jp:00000630", "sets": ["83"]}, "author_link": ["3482", "3486", "3490", "3492", "3491", "3493", "3485", "3488", "3487", "3489", "3484", "3483"], "item_10002_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "262", "bibliographicPageStart": "255", "bibliographicVolumeNumber": "25", "bibliographic_titles": [{"bibliographic_title": "The Showa University journal of medical sciences"}]}]}, "item_10002_description_6": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Glioblastoma (GBM) is difficult to completely cure by surgical treatment alone, and it is generally treated with a combination of surgery, radiotherapy, and chemotherapy. However, GBM is resistant to radiotherapy and chemotherapy, and complete cure cannot be achieved. Cancer stem cells (CSC) and survivin, which inhibit apoptosis, are considered as factors underlying tumor recurrence and the radiation- and drug-resistance of these tumors. We analyzed CSC and survivin expression in surgically excised specimens of malignant brain tumors to establish the relationships between the grades and CSC and survivin expression and between MIB-1 (Ki-67) expression and resistance. No relationship was noted between the grades and CSC or survivin expression, or between MIB-1 and CSC expression or between Grade 3 and 4 MIB-1 and survivin expression, although a correlation was noted between MIB-1 and survivin expression in Grade II tumors. These findings suggested that CSC are consistently contained in tumor tissue at a specific rate regardless of the histological grade, and the apoptosis of cells with low-level proliferative and cell cycling activities does not occur because these cells do not respond to chemotherapy or radiation, being resistant to treatment.", "subitem_description_type": "Abstract"}]}, "item_10002_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Showa University Society"}]}, "item_10002_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.15369/sujms.25.255", "subitem_relation_type_select": "DOI"}}]}, "item_10002_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10781651", "subitem_source_identifier_type": "NCID"}]}, "item_10002_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0915-6380", "subitem_source_identifier_type": "ISSN"}]}, "item_10002_text_26": {"attribute_name": "アイテムタイプ", "attribute_value_mlt": [{"subitem_text_value": "学内発行雑誌 / Departmental Bulletin Paper"}]}, "item_10002_text_27": {"attribute_name": "POS_INDEX", "attribute_value_mlt": [{"subitem_text_value": "学内発行雑誌/The Showa University journal of medical sciences/Vol.25(2013)/No.4"}]}, "item_10002_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "KOBAYASHI, Yusuke"}], "nameIdentifiers": [{"nameIdentifier": "3482", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SASAKI, Akiko"}], "nameIdentifiers": [{"nameIdentifier": "3483", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TSUJI, Mayumi"}], "nameIdentifiers": [{"nameIdentifier": "3484", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "UDAKA, Yuko"}], "nameIdentifiers": [{"nameIdentifier": "3485", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "OYAMADA, Hideto"}], "nameIdentifiers": [{"nameIdentifier": "3486", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TSUNODA, Yuko"}], "nameIdentifiers": [{"nameIdentifier": "3487", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "IWAI, Shinichi"}], "nameIdentifiers": [{"nameIdentifier": "3488", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SOMEI, Masayuki"}], "nameIdentifiers": [{"nameIdentifier": "3489", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KIZAKI, Junichiro"}], "nameIdentifiers": [{"nameIdentifier": "3490", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KONDO, Yasuyuki"}], "nameIdentifiers": [{"nameIdentifier": "3491", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SHIMIZU, Katsuyoshi"}], "nameIdentifiers": [{"nameIdentifier": "3492", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MIZUTANI, Tohru"}], "nameIdentifiers": [{"nameIdentifier": "3493", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-07-26"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "S25_255.pdf", "filesize": [{"value": "1.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1000000.0, "url": {"label": "S25_255.pdf", "url": "https://showa.repo.nii.ac.jp/record/630/files/S25_255.pdf"}, "version_id": "ee84ecf7-06cb-4153-8771-b200f8285c6e"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Relationship of Grade of Malignant Brain Tumor to Cancer Stem Cells and Survivin Expression", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Relationship of Grade of Malignant Brain Tumor to Cancer Stem Cells and Survivin Expression", "subitem_title_language": "en"}]}, "item_type_id": "10002", "owner": "1", "path": ["83"], "permalink_uri": "https://showa.repo.nii.ac.jp/records/630", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-01-18"}, "publish_date": "2017-01-18", "publish_status": "0", "recid": "630", "relation": {}, "relation_version_is_last": true, "title": ["Relationship of Grade of Malignant Brain Tumor to Cancer Stem Cells and Survivin Expression"], "weko_shared_id": 1}
Relationship of Grade of Malignant Brain Tumor to Cancer Stem Cells and Survivin Expression
https://showa.repo.nii.ac.jp/records/630
https://showa.repo.nii.ac.jp/records/630c4c3ca05-b255-43d5-a9dd-7a80f24b510d
名前 / ファイル | ライセンス | アクション |
---|---|---|
S25_255.pdf (1.0 MB)
|
|
Item type | 学内発行雑誌 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-01-18 | |||||
タイトル | ||||||
タイトル | Relationship of Grade of Malignant Brain Tumor to Cancer Stem Cells and Survivin Expression | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | departmental bulletin paper | |||||
著者 |
KOBAYASHI, Yusuke
× KOBAYASHI, Yusuke× SASAKI, Akiko× TSUJI, Mayumi× UDAKA, Yuko× OYAMADA, Hideto× TSUNODA, Yuko× IWAI, Shinichi× SOMEI, Masayuki× KIZAKI, Junichiro× KONDO, Yasuyuki× SHIMIZU, Katsuyoshi× MIZUTANI, Tohru |
|||||
書誌情報 |
The Showa University journal of medical sciences 巻 25, 号 4, p. 255-262, 発行日 2013-12 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Glioblastoma (GBM) is difficult to completely cure by surgical treatment alone, and it is generally treated with a combination of surgery, radiotherapy, and chemotherapy. However, GBM is resistant to radiotherapy and chemotherapy, and complete cure cannot be achieved. Cancer stem cells (CSC) and survivin, which inhibit apoptosis, are considered as factors underlying tumor recurrence and the radiation- and drug-resistance of these tumors. We analyzed CSC and survivin expression in surgically excised specimens of malignant brain tumors to establish the relationships between the grades and CSC and survivin expression and between MIB-1 (Ki-67) expression and resistance. No relationship was noted between the grades and CSC or survivin expression, or between MIB-1 and CSC expression or between Grade 3 and 4 MIB-1 and survivin expression, although a correlation was noted between MIB-1 and survivin expression in Grade II tumors. These findings suggested that CSC are consistently contained in tumor tissue at a specific rate regardless of the histological grade, and the apoptosis of cells with low-level proliferative and cell cycling activities does not occur because these cells do not respond to chemotherapy or radiation, being resistant to treatment. | |||||
DOI | ||||||
関連識別子 | 10.15369/sujms.25.255 | |||||
出版者 | ||||||
出版者 | Showa University Society | |||||
ISSN | ||||||
収録物識別子 | 0915-6380 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |