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アイテム
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Mesenchymal Stem Cells from Bone Marrow Enhance Neovascularization and Stromal Cell Proliferation in Rat Ischemic Limb in the Early Phase after plantation
https://showa.repo.nii.ac.jp/records/611
https://showa.repo.nii.ac.jp/records/61158528b37-275d-4d62-84e3-8796efee69f4
名前 / ファイル | ライセンス | アクション |
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S26_121.pdf (637.0 kB)
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Item type | 学内発行雑誌 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-05-09 | |||||
タイトル | ||||||
タイトル | Mesenchymal Stem Cells from Bone Marrow Enhance Neovascularization and Stromal Cell Proliferation in Rat Ischemic Limb in the Early Phase after plantation | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | departmental bulletin paper | |||||
著者 |
USUI, Sayaka
× USUI, Sayaka× ISO, Yoshitaka× SASAI, Masahiro× MIZUKAMI, Takuya× SATO, Chisato× KURATA, Masaaki× UMEZAWA, Akihiro× SHIODA, Seiji× SUZUKI, Hiroshi |
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書誌情報 |
The Showa University journal of medical sciences 巻 26, 号 2, p. 121-129, 発行日 2014-06 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Accumulating evidence from animal studies shows that the administration of mesenchymal stem cells (MSCs) from adult bone marrow ameliorates tissue damage after ischemic injury. In the present study we investigated the efficacy of MSC implantation into a hindlimb ischemia model over a short-term period to elucidate the effects conferred within the early phase after treatment. MSCs from rats expressing green fluorescence protein (GFP) were injected into rat ischemic limbs. Laser Doppler perfusion imaging revealed significantly higher blood perfusion recovery in the MSC group than in the control group on days 3 and 7 after the treatment. The capillary / muscle fiber ratio in ischemic muscle was also significantly higher in the MSC group than in the controls in a histological study. In spite of these benefits, we found no evident engraftment of the GFP-positive cells, and instead, the MSC treatment induced a proliferation of resident stromal cells in the perivascular area of the ischemic muscle, some of which produced vascular endothelial growth factor. The present study suggested that MSC therapy promotes neovascularization even in the early phase, both directly through endothelial proliferation and indirectly through activation of the resident stromal cells. | |||||
DOI | ||||||
関連識別子 | 10.15369/sujms.26.121 | |||||
出版者 | ||||||
出版者 | Showa University Society | |||||
ISSN | ||||||
収録物識別子 | 0915-6380 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |