WEKO3
アイテム
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CCR6+ MCAM+ Th17 Cell Numbers Increase in Patients with Psoriasis and Correlate with Disease Severity
https://showa.repo.nii.ac.jp/records/554
https://showa.repo.nii.ac.jp/records/5541c321712-8e76-4c56-b3fd-47ee78d7688d
名前 / ファイル | ライセンス | アクション |
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S28_173.pdf (4.3 MB)
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Item type | 学内発行雑誌 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2018-12-27 | |||||
タイトル | ||||||
タイトル | CCR6+ MCAM+ Th17 Cell Numbers Increase in Patients with Psoriasis and Correlate with Disease Severity | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | departmental bulletin paper | |||||
著者 |
KOBAYASHI, Kae
× KOBAYASHI, Kae× WATANABE, Hideaki× KAMIYAMA, Taisuke× SUEKI, Hirohiko× SASAKI, Yosuke× YAMOCHI, Toshiko× KOKAZE, Akatsuki× IWAMOTO, Sanju× TAKIMOTO, Masafumi |
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書誌情報 |
The Showa University journal of medical sciences 巻 28, 号 2, p. 173-181, 発行日 2016-06 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Psoriasis is a chronic immune-mediated disease in which the interleukin (IL)-23/IL-17 axis plays a key role in the inflammatory cascade. We recently reported that co-expression of CCR6 and melanoma cell adhesion molecule (MCAM) in effector memory CD4 T cells (TEM) of peripheral blood might be a useful marker for T helper (Th) 17 cells. In this study, we monitored changes in TEM expressing CCR6 and MCAM using the Psoriasis Area and Severity Index (PASI) score during anti-tumor necrosis factor (TNF) therapy. We also studied CCR6+ MCAM+ Th17 cells histologically in skin biopsy samples from psoriasis patients. In psoriasis patients treated with anti-TNF therapy, the PASI score and the percentage of CCR6+ MCAM+ TEM cells in the blood changed almost in parallel. In immunohistochemical analyses, the proportions of IL-17+ T cells and MCAM+ T cells in the lesional skin of severely psoriatic patients were significantly higher than in mildly psoriatic patients (P<0.05), and the number of IL17+ T cells correlated with the PASI score (r=0.400, P<0.05). Taken together, these results indicate that CCR6+ MCAM+ Th17 cells in peripheral blood and lesional skin might play an important role in the pathology of psoriasis. | |||||
DOI | ||||||
関連識別子 | 10.15369/sujms.28.173 | |||||
出版者 | ||||||
出版者 | Showa University Society | |||||
ISSN | ||||||
収録物識別子 | 0915-6380 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |