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Efficacy and Safety of Transcranial Magnetic Stimulation in Patients with Depression
https://showa.repo.nii.ac.jp/records/486
https://showa.repo.nii.ac.jp/records/486b14d4f86-6833-4825-a748-df451b04175b
名前 / ファイル | ライセンス | アクション |
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S30_97.pdf (122.9 kB)
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Item type | 学内発行雑誌 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2018-08-23 | |||||
タイトル | ||||||
タイトル | Efficacy and Safety of Transcranial Magnetic Stimulation in Patients with Depression | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | departmental bulletin paper | |||||
著者 |
KAWAGUCHI, Yu
× KAWAGUCHI, Yu× IWANAMI, Akira |
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書誌情報 |
The Showa University journal of medical sciences 巻 30, 号 1, p. 97-106, 発行日 2018-03 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Transcranial magnetic stimulation (TMS) could be a helpful addition to pharmacotherapy in treating depression; however, more evidence of its efficacy and safety is needed. This single-arm, open clinical study tested the efficacy and safety of TMS in 46 patients diagnosed with major depression or bipolar disorder. TMS was performed 30 times in total, with treatment frequencies of 3-5 times weekly. Patients were examined at the 10th and 20th treatments, after completion of TMS treatment, and at 2 and 4 weeks after completion of treatment. Primary efficacy endpoints were changes in Hamilton Depression Scale (HAMD-17) and Patient Health Questionnaire (PHQ-9) scores from baseline. Mean scores and changes in HAMD-17 and PHQ-9 were significantly decreased from baseline. The response rate at completion of treatment was 68.57%. Systolic blood pressure was significantly decreased at 4 weeks after completion of treatment. Adverse events were observed in 10 patients (21.74%), including headache, discomfort, and fatigue. The present study found that patients with major depression or bipolar disorder who received TMS showed significant improvement in HAMD-17, PHQ-9, and Clinical Global Impression Scale scores. | |||||
DOI | ||||||
関連識別子 | 10.15369/sujms.30.97 | |||||
出版者 | ||||||
出版者 | Showa University Society | |||||
ISSN | ||||||
収録物識別子 | 0915-6380 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |