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アイテム
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Comparative Study of a Proton Pump Inhibitor with a Histamine H2 Receptor Antagonist in Japanese Patients with Functional Dyspepsia
https://showa.repo.nii.ac.jp/records/481
https://showa.repo.nii.ac.jp/records/48120737f78-bddc-4d0e-9bac-3e10365add6d
名前 / ファイル | ライセンス | アクション |
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S30_43.pdf (109.0 kB)
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Item type | 学内発行雑誌 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2018-08-23 | |||||
タイトル | ||||||
タイトル | Comparative Study of a Proton Pump Inhibitor with a Histamine H2 Receptor Antagonist in Japanese Patients with Functional Dyspepsia | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | departmental bulletin paper | |||||
著者 |
TASHIRO, Tomoe
× TASHIRO, Tomoe× TAKEUCHI, Yoshiaki× SAKURAI, Yukihiro× ARAI, Makoto× SHIBATA, MinorI× TAZAKI, Shuhei× NISHIKAWA, Junichi× YOSHIDA, Hitoshi |
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書誌情報 |
The Showa University journal of medical sciences 巻 30, 号 1, p. 43-52, 発行日 2018-03 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The present study sought to compare the effectiveness of a proton pump inhibitor (PPI) with that of a histamine H2 receptor antagonist (H2RA) for treating functional dyspepsia (FD) in a real-world setting. A multicenter, open-label, randomized trial was conducted. FD patients were randomly assigned to receive either 20mg, q.d., omeprazole (OPZ; a PPI) or 150mg, b.i.d., ranitidine hydrochloride (RAN; an H2RA) for 4 weeks. Any change in the total Gastrointestinal Symptom Rating Scale (GSRS) score (delta) at week 4 was the primary outcome measure. Secondary outcome measures were reductions in scores for individual items on the GSRS at week 4. As a subanalysis, patients were stratified according to Helicobacter pylori serology and the analyses were repeated. The mean (±SD) deltas in total GSRS score for the OPZ and RAN groups were 0.8±0.7 and 0.6±0.6, respectively (P=0.098); however, the delta in reflux score between the OPZ and RAN groups differed significantly (1.1±0.7 vs. 0.5±0.5, respectively; P=0.001). There were no significant differences between the two groups in any other scores for individual items on the GSRS. The results of the subanalysis were like those of the main analysis. The PPI and H2RA produced a comparable improvement in symptoms of FD in our patient cohort, thus we propose no advantage would be gained in using a PPI rather than an H2RA. | |||||
DOI | ||||||
関連識別子 | 10.15369/sujms.30.43 | |||||
出版者 | ||||||
出版者 | Showa University Society | |||||
ISSN | ||||||
収録物識別子 | 0915-6380 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |