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Dose-Volume Histogram Analysis in Point A-based Dose Prescription of High-dose-rate Brachytherapy for Cervical Carcinoma
https://showa.repo.nii.ac.jp/records/470
https://showa.repo.nii.ac.jp/records/470781eac8f-eb7e-41c8-813d-fb8063431f53
名前 / ファイル | ライセンス | アクション |
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S30_227.pdf (336.1 kB)
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Item type | 学内発行雑誌 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2018-09-03 | |||||
タイトル | ||||||
タイトル | Dose-Volume Histogram Analysis in Point A-based Dose Prescription of High-dose-rate Brachytherapy for Cervical Carcinoma | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | departmental bulletin paper | |||||
著者 |
KOBAYASHI, Rei
× KOBAYASHI, Rei× KAGAMI, Yoshikazu× SHINJO, Hidenori× MURAKAMI, Kouzou× MIYAURA, Kazunori× OZAWA, Yukiko× KATO, Masako× NIIYA, Akifumi× MATSUMOTO, Koji× MOROTA, Madoka× OKABE, Naoyuki |
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書誌情報 |
The Showa University journal of medical sciences 巻 30, 号 2, p. 227-235, 発行日 2018-06 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Traditionally, cervical brachytherapy has been prescribed to point A. However, since the Groupe Europ?en de Curieth?rapie and European Society for Radiotherapy& Oncology guidelines were published, image-guided brachytherapy has become an emerging technique. The purpose of this study was to evaluate the high-risk clinical target volume (HR-CTV) coverage and analyze dose-volume histograms for organs at risk in point A prescription of high-dose-rate brachytherapy. A total of 68 patients with locally advanced cervical cancer were treated with three-dimensional conformal external beam radiation therapy and brachytherapy from December 2012 to March 2017. Fractions of 6Gy for a total of 12-24Gy were delivered at point A by brachytherapy to all patients. Following each brachytherapy application, a pelvic computed tomography scan was performed and imported into a three-dimensional brachytherapy treatment planning system. In this study, the HR-CTV, bladder, and rectum were re-delineated according to Report 89 of the International Commission on Radiation Units and Measurements using the magnetic resonance images at the time of diagnosis, and the dose-volume histogram of each structure was analyzed. The median age of patients at diagnosis was 67 years (range, 31-91 years). Mean HR-CTV D90 for all patients was 558.3cGy (range, 228.7-1005.1cGy) and the mean HR-CTV D90 within each clinical T stage was: Ib, 646.4cGy; 2a, 579.3cGy; 2b, 545.2cGy; 3a, 556.6cGy; 3b, 451.3cGy; and 4, 497.9cGy. HR-CTVD90 was correlated with HR-CTV. The mean D2cm3 was 678.1cGy for the bladder and 511.9cGy for the rectum. Using point A-based dose prescription, HR-CTV coverage was insufficient, especially in cases with a large tumor volume or a high T stage. Image-guided brachytherapy is expected to improve HR-CTV coverage while keeping rectal and bladder doses within acceptable levels. | |||||
DOI | ||||||
関連識別子 | 10.15369/sujms.30.227 | |||||
出版者 | ||||||
出版者 | Showa University Society | |||||
ISSN | ||||||
収録物識別子 | 0915-6380 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |