| Item type |
学内発行雑誌 / Departmental Bulletin Paper(1) |
| 公開日 |
2023-04-07 |
| タイトル |
|
|
タイトル |
Genotypic characterization Escherichia coli strains from Japan producing AmpC beta-lactamase |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
departmental bulletin paper |
| 著者 |
YAMOCHI, Tadanori
YOSHIDA, Katsuhiko
OHIRA, Yasuyuki
OTA, Hirotaka
YAMOCHI, Toshiko
TAKIMOTO, Masafumi
TOKIMATSU, Issei
|
| 書誌情報 |
The Showa University journal of medical sciences
巻 34,
号 4,
p. 183-190,
発行日 2022-12
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
AmpC is a class C Ambler β-lactamase that confers resistance to cephamycins. Globally reported AmpC-producing Enterobacterales are clinically important due to their therapeutic restrictions and epidemiology. Between April 2021 and May 2021, an outbreak of AmpC beta-lactamase-producing Escherichia coli occurred at Showa University Hospital. Because of this outbreak, plasmid typing, enterobacterial repetitive intergenic consensus-polymerase chain reaction （ERIC-PCR） analysis, conjugation experiments, and pulsed-field gel electrophoresis （PFGE） were performed to study the molecular epidemiological characteristics of these E. coli strains. ERIC-PCR and conjugation experiments detected IncFrepB＋, IncFIA＋, and IncFIB＋ multiple-replicon conjugative plasmids carrying the AmpC gene （blaDHA-1）. Five of eleven isolates showed the same PFGE banding pattern in the XbaI-digested genomic DNA, whereas the remaining six strains displayed minor variants. These data highlight the need for improvements to infection control and surveillance measures to prevent the spread of blaDHA-1-carrying E. coli strains. |
| DOI |
|
|
|
関連識別子 |
10.15369/sujms.34.183 |
| 出版者 |
|
|
出版者 |
Showa University Society |
| ISSN |
|
|
収録物識別子 |
2185-0968 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
S34_183.pdf (363.6 kB)
