| Item type |
学内発行雑誌 / Departmental Bulletin Paper(1) |
| 公開日 |
2022-04-04 |
| タイトル |
|
|
タイトル |
Tumor protein D54: A promising marker of mucoepidermoid carcinoma |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
departmental bulletin paper |
| 著者 |
YASO, Atsutoshi
KAMATANI, Takaaki
MUKUDAI, Yoshiki
ABE, Yuzo
SHIROTA, Tatsuo
|
| 書誌情報 |
The Showa University journal of medical sciences
巻 34,
号 1,
p. 1-10,
発行日 2022-03
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
A definitive diagnosis of salivary gland tumors is extremely difficult to make without evaluating the entire tumor and conducting immunohistochemical examinations. In this study, we aimed to examine and compare the expression patterns of the tumor protein （TP） D52 family, including TPD52, TPD53, and TPD54, in salivary gland tumor cells by using immunohistochemical staining. Among over 30 benign and malignant salivary gland tumors with extensive and diverse morphological features and overlapping histological similarities, we selected Warthin’s tumor and pleomorphic adenoma to represent benign salivary gland tumors and mucoepidermoid carcinoma to represent malignant ones. Tumor samples were fixed in 10％ buffered formalin and embedded in paraffin. Then, immunohistochemical staining was performed using antibodies against TPD52, TPD53, and TPD54. Neither the benign salivary gland tumors nor mucoepidermoid carcinoma stained for TPD52. However, the intensity of TPD53 and TPD54 staining was found to be low in the benign salivary gland tumors and high in mucoepidermoid carcinoma. TPD54 may serve as a pathological indicator of benign salivary gland tumors and mucoepidermoid carcinoma. |
| DOI |
|
|
|
関連識別子 |
10.15369/sujms.34.1 |
| 出版者 |
|
|
出版者 |
Showa University Society |
| ISSN |
|
|
収録物識別子 |
2185-0968 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
S34_1.pdf (1.1 MB)
