WEKO3
アイテム
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Persistence of Cryoglobulinemia in Patients with Chronic Hepatitis C after Successful Treatment with Direct-acting Antivirals
https://showa.repo.nii.ac.jp/records/3044
https://showa.repo.nii.ac.jp/records/30445fec1893-083e-4b82-b8c3-3089acaf3d81
名前 / ファイル | ライセンス | アクション |
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S31_253.pdf (156.7 kB)
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Item type | 学内発行雑誌 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-11-29 | |||||
タイトル | ||||||
タイトル | Persistence of Cryoglobulinemia in Patients with Chronic Hepatitis C after Successful Treatment with Direct-acting Antivirals | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | departmental bulletin paper | |||||
著者 |
NAKAJIMA, Yoko
× NAKAJIMA, Yoko× UCHIKOSHI, Manabu× WANG, Tianpeng× SUGIURA, Ikuya× KAJIWARA, Atsushi× ARAI, Jun× UOZUMI, Shojiro× SHIMOZUMA, Yuu× SAKAKI, Masashi× NOMURA, Norihiro× EGUCHI, Junichi× NOZAWA, Hisako× KURIHARA, Toshikazu× ITO, Takayoshi× YOSHIDA, Hitoshi |
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書誌情報 |
The Showa University journal of medical sciences 巻 31, 号 3, p. 253-262, 発行日 2019-09 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Hepatitis C virus(HCV)infection can cause chronic liver disease; it has also been associated with lymphoproliferative disorders(LPDs), such as cryoglobulinemia and B-cell non-Hodgkin’s lymphoma. Our previous studies suggested that cryoglobulinemia, high titer of rheumatoid factor(RF), and hypocomplementemia are immunological markers of LPDs. In addition, recent therapies with direct-acting antivirals(DAAs)have achieved high rates of sustained virological response(SVR)in patients with chronic hepatitis C(CH-C). This study analyzed the efficacy of DAA therapy in CH-C patients with cryoglobulinemia, and the association of biochemical and other immune markers for LPDs with persistence of cryoglobulinemia in patients after DAA therapy. Of 226 patients tested, 31(13.7%)had cryoglobulinemia prior to receiving DAAs, and these individuals showed lower complement 4 levels, decreased complement hemolytic activity, and higher IgM than patients without cryoglobulinemia. Of the 24 cryoglobulinemia-positive patients(83%)who could be followed for 24 weeks, 20 became cryoglobulinemia negative after the therapy. The remaining four patients retained the abnormal LPD markers, indicating the possibility of long-term LPD persistence even following successful eradication of HCV in CH-C patients. Thus, long-term follow-up is recommended to avoid exacerbation of extrahepatic manifestations as well as new events. | |||||
DOI | ||||||
関連識別子 | 10.15369/sujms.31.253 | |||||
出版者 | ||||||
出版者 | Showa University Society | |||||
ISSN | ||||||
収録物識別子 | 0915-6380 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |