| Item type |
学内発行雑誌 / Departmental Bulletin Paper(1) |
| 公開日 |
2016-11-17 |
| タイトル |
|
|
タイトル |
Direct Bone Destruction by Neutrophils in Collagen-induced Arthritis Treated with Bisphosphonates |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
departmental bulletin paper |
| 著者 |
NAKAYAMA, Mayuko
YAGI, Hideki
ENDO, Yasuo
MAKI, Koutaro
NAKAMURA, Masanori
|
| 書誌情報 |
Dental medicine research
巻 30,
号 3,
p. 211-218,
発行日 2010-11
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
To identify the direct destruction of bone by neutrophils in collagen-induced arthritis treated with powerful anti-osteoclastic bone resorptive agents, bisphosphonates, we designed the experiments to examine whether the bone destruction induced by collagen-induced arthritis (CIA) was inhibited by nitrogen-containing bisphosphonates (NBPs) or not, and examined histologically and ultrastructually to detect the cells directly related to bone destruction. One of the representative NBPs, alendronate (1.6 µmol/kg), was injected once a week from one week before the onset of the first sensitization with type II collagen. Flow cytometric analysis indicated the enhanced granulopoiesis in both BP-treated and non-treated CIA mice. Severe bone destruction was detected in both saline-group and alendronate-group. Although many active osteoclasts were developed on the destructive bone in saline-group, almost no active osteoclasts were detected in alendronate-group, where many neutrophils were accumulated. Some of neutrophils accumulated on the destructive bone were ruptured and cytoplasmic granules were scattered extracellularly, where collagen fibers were no longer detected. These results indicated that the bone destruction in CIA mice was not prevented by the injection of NBP and suggested that neutrophils in addition to osteoclasts might directly have the capacity for the bone destruction. |
| DOI |
|
|
|
関連識別子 |
10.7881/dentalmedres.30.211 |
| 出版者 |
|
|
出版者 |
昭和大学・昭和歯学会 |
| ISSN |
|
|
収録物識別子 |
1882-0719 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
D30_211.pdf (2.3 MB)
