| Item type |
学内発行雑誌 / Departmental Bulletin Paper(1) |
| 公開日 |
2016-12-19 |
| タイトル |
|
|
タイトル |
Expression of Standard CD44 in Advanced Gastric Cancer: Relationship with Metastasis to Lymph Nodes |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
departmental bulletin paper |
| 著者 |
ARIMA, Shuei
KUNIMURA, Toshiaki
DATE, Hiromi
MATSUO, Kai
MORI, Tomoaki
OCHIAI, Yasuo
KITAYAMA, Takeyoshi
MOROHOSHI, Toshio
|
| 書誌情報 |
The Showa University journal of medical sciences
巻 22,
号 3,
p. 163-169,
発行日 2010-09
|
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Standard CD44 (CD44s) is reported to play an important role in determining the malignant potential of various carcinomas. The aim of the present study was to evaluate CD44s expression in T2-T3 gastric cancer (Japanese Classification of Gastric Cancer stages MP, SS, SE) and the relationship between CD44s expression and clinicopathological parameters. CD44s expression was measured using immunohistochemistry in tumors from 98 patients with primary gastric cancer. Cases were categorized into two groups based on CD44s staining; the CD44s positive group had > 10% positively stained tumor cells and the CD44s negative group had < 10%. CD44s positivity was demonstrated in 59.1% (58/98) of tumors. CD44s expression showed no significant relationship with patient age or gender, or tumor location, size or macroscopic/microscopic classification. However, CD44s expression showed a significantly negative relationship with metastasis to lymph nodes (p < 0.0001). Thus, in T2-T3 gastric cancer, loss of CD44s expression suggests that metastasis of the tumor to lymph nodes is likely. |
| DOI |
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|
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関連識別子 |
10.15369/sujms.22.163 |
| 出版者 |
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出版者 |
Showa Medical Association and Showa University |
| ISSN |
|
|
収録物識別子 |
0915-6380 |
| 出版タイプ |
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|
出版タイプ |
VoR |
S22_163.pdf (267.7 kB)
