WEKO3
アイテム
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Effects of Interleukin-4-Transduced Tumor Cell Vaccines and Blockade of Programmed Cell Death 1 on the Growth of Established Tumors
https://showa.repo.nii.ac.jp/records/682
https://showa.repo.nii.ac.jp/records/682dbee2b0b-18b7-4020-b5d0-752f87ceda32
名前 / ファイル | ライセンス | アクション |
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S24_127.pdf (256.2 kB)
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Item type | 学内発行雑誌 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-11-28 | |||||
タイトル | ||||||
タイトル | Effects of Interleukin-4-Transduced Tumor Cell Vaccines and Blockade of Programmed Cell Death 1 on the Growth of Established Tumors | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | departmental bulletin paper | |||||
著者 |
OMORI, Risa
× OMORI, Risa× EGUCHI, Junichi× HIROISHI, Kazumasa× ISHII, Shigeaki× SASAGAWA, Ayako× SAKAKI, Masashi× DOI, Hiroyoshi× KAJIWARA, Atsushi× IMAWARI, Michio |
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書誌情報 |
The Showa University journal of medical sciences 巻 24, 号 2, p. 127-137, 発行日 2012-06 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Interleukin (IL)-4 exhibits strong antitumor effects and IL-4 gene therapy has been used clinically in the treatment of some types of cancer. In the present study, we evaluated the efficacy of IL-4-transduced tumor cell vaccines in combination with blockade of programmed cell death 1 (PD-1) and investigated the mechanisms underlying the antitumor effects of this therapy. A poorly immunogenic murine colorectal cancer cell line (i.e. MC38) was transduced to overexpress IL-4. In a therapeutic model, MC38-IL4 cells and anti-PD-1 antagonistic antibodies (Ab) were inoculated into parental tumor-bearing mice. Immunohistochemical analyses and tumor-specific lysis were also performed. Additive antitumor effects were observed when mice were treated with IL-4 in combination with an anti-PD-1 Ab. Immunohistochemical analysis of the therapeutic model showed marked infiltration of CD4+ and CD8+ cells into established MC38 tumors of mice treated with anti-PD-1 Ab. Significant tumor-specific cytolysis was detected when the splenocytes of mice treated with both IL-4 and anti-PD-1 Ab were used as effector cells. These results suggest that blockade of the interaction between PD-1 and programmed death ligand 1 (PD-L1) enhances the antitumor immune responses induced by IL-4. Thus, IL-4 gene-transduced tumor cell vaccines in combination with PD-1 blockade may be considered as possible candidates for clinical trials of new cancer vaccines. | |||||
DOI | ||||||
関連識別子 | 10.15369/sujms.24.127 | |||||
出版者 | ||||||
出版者 | Showa Medical Association and Showa University | |||||
ISSN | ||||||
収録物識別子 | 0915-6380 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |