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  1. 学内発行雑誌
  2. The Showa University journal of medical sciences
  3. Vol.28(2016)
  4. No.1

Pleiotropic Effects of Linagliptin Monotherapy on Levels of Nitric Oxide, Nitric Oxide Synthase, and Superoxide Dismutase in Hemodialysis Patients with Diabetes

https://showa.repo.nii.ac.jp/records/556
https://showa.repo.nii.ac.jp/records/556
3379280b-1a49-4192-b477-25e45416dd98
名前 / ファイル ライセンス アクション
S28_9.pdf S28_9.pdf (194.4 kB)
Item type 学内発行雑誌 / Departmental Bulletin Paper(1)
公開日 2017-02-14
タイトル
タイトル Pleiotropic Effects of Linagliptin Monotherapy on Levels of Nitric Oxide, Nitric Oxide Synthase, and Superoxide Dismutase in Hemodialysis Patients with Diabetes
言語 en
言語
言語 eng
資源タイプ
資源タイプ departmental bulletin paper
著者 KIMURA, Kengo

× KIMURA, Kengo

KIMURA, Kengo

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NAKAMURA, Yuya

× NAKAMURA, Yuya

NAKAMURA, Yuya

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HASEGAWA, Hitomi

× HASEGAWA, Hitomi

HASEGAWA, Hitomi

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TSUJI, Mayumi

× TSUJI, Mayumi

TSUJI, Mayumi

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OGUCHI, Tatsunori

× OGUCHI, Tatsunori

OGUCHI, Tatsunori

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TSUCHIYA, Hiromichi

× TSUCHIYA, Hiromichi

TSUCHIYA, Hiromichi

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GOTOH, Hiromichi

× GOTOH, Hiromichi

GOTOH, Hiromichi

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GOTO, Yoshikazu

× GOTO, Yoshikazu

GOTO, Yoshikazu

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INAGAKI, Masahiro

× INAGAKI, Masahiro

INAGAKI, Masahiro

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OGUCHI, Katsuji

× OGUCHI, Katsuji

OGUCHI, Katsuji

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書誌情報 The Showa University journal of medical sciences

巻 28, 号 1, p. 9-17, 発行日 2016-03
抄録
内容記述タイプ Abstract
内容記述 Linagliptin is an anti-diabetic drug and the only bile-excreted dipeptidyl peptidase-4 inhibitor. Malnutrition-inflammation-atherosclerosis syndrome is an important prognostic factor for hemodialysis patients, and we previously reported anti-inflammatory effects of linagliptin in hemodialysis patients with diabetes. Inflammation can accelerate oxidative stress, vasoconstriction, and platelet aggregation. However, few studies have investigated the pleiotropic effects of linagliptin treatment on inflammation in hemodialysis patients. In this study, we have extended our previous investigations of these effects in a longer and more thorough follow-up of hemodialysis patients with diabetes. We examined 20 hemodialysis patients with diabetes who were not receiving oral diabetes drugs or insulin therapy and who exhibited inadequate glycemic control (glycated albumin levels>20%). Linagliptin (5mg) was administered daily, and we evaluated the patients’ superoxide dismutase, 8-hydroxydeoxyguanosine, nitric oxide, nitric oxide synthase, and asymmetric dimethylarginine levels in serum at baseline and after 1, 3, and 6 months of treatment. After 6 months of treatment, superoxide dismutase levels had significantly decreased from 8.8±0.5U/ml to 7.0±0.5U/ml. Nitric oxide synthase levels were significantly increased at 3 and 6 months (maximum, 94.2±13.2µg/ml; baseline, 31.6±5.5µg/ml). After 3 months of treatment, nitric oxide levels had significantly increased from 64.5±6.6µmol/l to 104±15.4µmol/l, and remained significantly elevated at 6 months. Asymmetric dimethylarginine and 8-hydroxydeoxyguanosine levels did not change during the 6-month treatment course, and no patients exhibited hypoglycemia or other significant adverse effects. Linagliptin treatment significantly changed various markers of inflammation relevant to the atherosclerosis in malnutrition-inflammation-atherosclerosis syndrome. Therefore, linagliptin monotherapy has pleiotropic effects on inflammation in hemodialysis patients with diabetes, and may improve their prognosis.
DOI
関連タイプ isIdenticalTo
関連識別子 10.15369/sujms.28.9
出版者
出版者 Showa University Society
ISSN
収録物識別子タイプ ISSN
収録物識別子 0915-6380
出版タイプ
出版タイプ VoR
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