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  1. 学内発行雑誌
  2. The Showa University journal of medical sciences
  3. Vol.29(2017)
  4. No.4

Thrombomodulin can Predict the Incidence of Second Events in Patients with Acute Myocardial Infarction

https://showa.repo.nii.ac.jp/records/495
https://showa.repo.nii.ac.jp/records/495
79feb6f5-e74b-42ed-8678-06b08bd54abd
名前 / ファイル ライセンス アクション
S29_403.pdf S29_403.pdf (351.6 kB)
Item type 学内発行雑誌 / Departmental Bulletin Paper(1)
公開日 2018-04-20
タイトル
タイトル Thrombomodulin can Predict the Incidence of Second Events in Patients with Acute Myocardial Infarction
言語
言語 eng
資源タイプ
資源タイプ departmental bulletin paper
著者 KOSAKI, Ryota

× KOSAKI, Ryota

KOSAKI, Ryota

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MINOURA, Yoshino

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MINOURA, Yoshino

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NOMURA, Kosuke

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NOMURA, Kosuke

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SAKAI, Koshiro

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SAKAI, Koshiro

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SEKIMOTO, Teruo

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SEKIMOTO, Teruo

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NISHIKURA, Tenjin

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NISHIKURA, Tenjin

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HOSOKAWA, Satoshi

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HOSOKAWA, Satoshi

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TSUJITA, Hiroaki

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TSUJITA, Hiroaki

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KONDO, Seita

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KONDO, Seita

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TSUKAMOTO, Shigeto

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TSUKAMOTO, Shigeto

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MUTO, Mitsunori

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MUTO, Mitsunori

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HAMAZAKI, Yuji

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HAMAZAKI, Yuji

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KOBAYASHI, Youichi

× KOBAYASHI, Youichi

KOBAYASHI, Youichi

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書誌情報 The Showa University journal of medical sciences

巻 29, 号 4, p. 403-413, 発行日 2017-12
抄録
内容記述タイプ Abstract
内容記述 Biomarkers of atherothrombosis can predict the risk of cardiovascular events. However, it is difficult to predict second adverse events using these biomarkers at the point in time when the first cardiovascular event occurs. Therefore, we evaluated atherothrombosis-related biomarkers to determine their associations with prognosis after percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) patients. A total of 309 AMI patients were enrolled in this study. The patients had undergone successful coronary interventions and the levels of various atherothrombosis-related biomarkers were assessed within the first postoperative hour. Biomarkers other than those assessed by routine biochemical tests were analyzed, including defined endothelial cell damage markers such as thrombomodulin (TM), inflammatory markers such as C-reactive protein (CRP), and coagulation and fibrinolysis system markers such as D-dimer, prothrombin fragment F1+2 (F1+2) and plasminogen activator inhibitor-1 (PAI-1). Major adverse cardiac events (MACEs) occurred in 98 patients during the follow-up period (872.6±579.8 days). Multivariate analysis revealed that clinical parameters such as decreased levels of left ventricular ejection fraction and elevated levels of brain natriuretic peptide, hemoglobin A1c and TM were significantly associated with MACEs. The association between TM and MACEs was especially high (OR: 3.65, 95% CI; 1.75–7.68). Neither dyslipidemia, hypertension, smoking, advanced age, a history of cardiac events nor the type of AMI were associated with MACEs. TM is independently associated with MACEs and may be predictive of second events following PCI in patients with AMI.
DOI
関連識別子 10.15369/sujms.29.403
出版者
出版者 Showa University Society
ISSN
収録物識別子 0915-6380
出版タイプ
出版タイプ VoR
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