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Effectiveness of Therapeutic Monoclonal Antibodies for Asthma Control in Uncontrolled Eosinophilic Asthma-A Meta-analysis of Randomized Controlled Trials-
https://showa.repo.nii.ac.jp/records/475
https://showa.repo.nii.ac.jp/records/475faf0d161-932e-470a-be1d-29c351d3662a
名前 / ファイル | ライセンス | アクション |
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S30_297.pdf (546.3 kB)
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Item type | 学内発行雑誌 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2018-09-03 | |||||
タイトル | ||||||
タイトル | Effectiveness of Therapeutic Monoclonal Antibodies for Asthma Control in Uncontrolled Eosinophilic Asthma-A Meta-analysis of Randomized Controlled Trials- | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | departmental bulletin paper | |||||
著者 |
ANDO, Koichi
× ANDO, Koichi× TANAKA, Akihiko× OHNISHI, Tsukasa× INOUE, Shin× SAGARA, Hironori |
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書誌情報 |
The Showa University journal of medical sciences 巻 30, 号 2, p. 297-307, 発行日 2018-06 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The overall efficacy of therapeutic monoclonal antibodies (mAbs) for asthma control in patients with uncontrolled eosinophilic asthma remains to be fully characterized. We conducted a meta-analysis of randomized controlled trials (RCTs) to analyze the efficacies of new therapeutic mAbs, such as anti-interleukin (IL)-13 therapies, anti-IL4/13 therapies, and anti-IL-5 therapies, compared with that of a placebo in patients with uncontrolled asthma. This meta-analysis complies with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The primary efficacy outcome was asthma control as assessed by Asthma Control Questionnaire (ACQ) scores. Pooled estimates are presented as standardized mean differences (Std MDs) with 95% confidence intervals (CIs). Seven RCTs of therapeutic mAbs, including anti-IL-13, anti-IL-4/13, and anti-IL-5, met the criteria for study inclusion. The overall Std MD of changes in the ACQ score was −0.31 (95% CI, −0.45 to −0.17; P<0.0001). These results strongly indicate that therapeutic mAbs are effective in controlling asthma in patients with uncontrolled eosinophilic asthma. | |||||
DOI | ||||||
関連識別子 | 10.15369/sujms.30.297 | |||||
出版者 | ||||||
出版者 | Showa University Society | |||||
ISSN | ||||||
収録物識別子 | 0915-6380 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |