| Item type |
学内発行雑誌 / Departmental Bulletin Paper(1) |
| 公開日 |
2020-08-19 |
| タイトル |
|
|
タイトル |
Simple Stratification of Hepatocellular Carcinoma Surveillance after Direct-acting Antiviral Therapy for Chronic Hepatitis C |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
departmental bulletin paper |
| 著者 |
WANG, Tianpeng
SAKAKI, Masashi
ICHIKAWA, Yuki
OTOYAMA, Yumi
NAKAJIMA, Yoko
SUGIURA, Ikuya
ARAI, Jun
KAJIWARA, Atsushi
UOZUMI, Shojiro
SHIMOZUMA, Yuu
UCHIKOSHI, Manabu
YOSHIDA, Hitoshi
|
| 書誌情報 |
The Showa University journal of medical sciences
巻 32,
号 2,
p. 125-133,
発行日 2020-07
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Reports on surveillance systems useful for determining the risk of developing hepatocellular carcinoma （HCC） after direct-acting antiviral （DAA） treatment for hepatitis C have been published. Liver cirrhosis （LC） is a high-risk factor for HCC, but the evaluation frequency necessary for patients with chronic hepatitis （CH） remains unknown. Here, we aimed to identify how frequent CH patients should be evaluated for HCC, with particular emphasis on patients achieving a sustained virological response （SVR） with DAA treatment. Data were collected pre-treatment （Pre） and at the time of SVR for 141 patients with hepatitis C receiving DAA treatment. We defined LC by a platelet （PLT） count ≤10×104/µl, and CH was defined by a PLT count of ＞10×104/µl. The incidence of HCC in patients with CH after achieving SVR was retrospectively evaluated. In total, 128 patients （CH, n＝102; LC, n＝26） achieved SVR, and 13 developed HCC after SVR during the follow-up period （mean, 748 days）. Although fibrosis-4 （FIB-4） index, the presence of α-fetoprotein, and prothrombin time were significant risk factors for HCC in patients with CH in the univariate analysis, only the Pre-FIB-4 index was an independent predictive factor for HCC development in the multivariate analysis （p＝0.04）. An FIB-4 index ≥3 was a significant risk factor for HCC （p＝0.005）. The cumulative risk for HCC at 1000 days was 2.6％ and 24.2％ in the FIB-4 index ＜3 and FIB-4 index ≥3 groups, respectively （p＝0.004）. Frequent HCC examination is recommended for FIB-4 index ≥3 CH patients who obtain SVR after DAA treatment. |
| DOI |
|
|
|
関連識別子 |
10.15369/sujms.32.125 |
| 出版者 |
|
|
出版者 |
Showa University Society |
| ISSN |
|
|
収録物識別子 |
2185-0968 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
S32_125.pdf (137.4 kB)
