| Item type |
学内発行雑誌 / Departmental Bulletin Paper(1) |
| 公開日 |
2019-11-29 |
| タイトル |
|
|
タイトル |
Persistence of Cryoglobulinemia in Patients with Chronic Hepatitis C after Successful Treatment with Direct-acting Antivirals |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
departmental bulletin paper |
| 著者 |
NAKAJIMA, Yoko
UCHIKOSHI, Manabu
WANG, Tianpeng
SUGIURA, Ikuya
KAJIWARA, Atsushi
ARAI, Jun
UOZUMI, Shojiro
SHIMOZUMA, Yuu
SAKAKI, Masashi
NOMURA, Norihiro
EGUCHI, Junichi
NOZAWA, Hisako
KURIHARA, Toshikazu
ITO, Takayoshi
YOSHIDA, Hitoshi
|
| 書誌情報 |
The Showa University journal of medical sciences
巻 31,
号 3,
p. 253-262,
発行日 2019-09
|
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Hepatitis C virus（HCV）infection can cause chronic liver disease; it has also been associated with lymphoproliferative disorders（LPDs）, such as cryoglobulinemia and B-cell non-Hodgkin’s lymphoma. Our previous studies suggested that cryoglobulinemia, high titer of rheumatoid factor（RF）, and hypocomplementemia are immunological markers of LPDs. In addition, recent therapies with direct-acting antivirals（DAAs）have achieved high rates of sustained virological response（SVR）in patients with chronic hepatitis C（CH-C）. This study analyzed the efficacy of DAA therapy in CH-C patients with cryoglobulinemia, and the association of biochemical and other immune markers for LPDs with persistence of cryoglobulinemia in patients after DAA therapy. Of 226 patients tested, 31（13.7％）had cryoglobulinemia prior to receiving DAAs, and these individuals showed lower complement 4 levels, decreased complement hemolytic activity, and higher IgM than patients without cryoglobulinemia. Of the 24 cryoglobulinemia-positive patients（83％）who could be followed for 24 weeks, 20 became cryoglobulinemia negative after the therapy. The remaining four patients retained the abnormal LPD markers, indicating the possibility of long-term LPD persistence even following successful eradication of HCV in CH-C patients. Thus, long-term follow-up is recommended to avoid exacerbation of extrahepatic manifestations as well as new events. |
| DOI |
|
|
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関連識別子 |
10.15369/sujms.31.253 |
| 出版者 |
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|
出版者 |
Showa University Society |
| ISSN |
|
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収録物識別子 |
0915-6380 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
S31_253.pdf (156.7 kB)
